Decoding the Role of DVL1 in Intracranial Meningioma
Abstract
:1. Introduction
2. Results
2.1. Genetic Instability of the DVL1 Gene Recorded with the D1S468 Marker
2.2. Mutations in the PDZ Region of the DVL1 Gene
2.3. Protein Expression and Localization of the DVL1 and Active β-Catenin Form
3. Discussion
4. Materials and Methods
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Location of Mutation | Type of Mutation | Number of Samples with This Type of Mutation |
---|---|---|
Intron 7 | NG_008048.2: g.13921delT | 7 |
Intron 7 | NG_008048.2: g.13921T>C | 4 |
Exon 8 | NG_008048.2: g.13998delA | 1 |
Exon 8 | NG_008048.2: g.14004delA | 9 |
Exon 8 | NG_008048.2: g.14004A>T | 1 |
Intron 8 | NG_008048.2: g.14228_14267dup | 25 |
Intron 8 | NG_008048.2: g.14248G>T | 1 |
Intron 8 | NG_008048.2: g.14300G>T | 1 |
Exon 9 | NG_008048.2: g.14329G>C | 1 |
(Pre) Denaturation | Denaturation | Annealing | Extending | No. of Cycles | |
---|---|---|---|---|---|
D1S468 | 94 °C/5 min | 94 °C/30 s | 60 °C/30 s | 72 °C/30 s | 40 |
PDZ | 94 °C/5 min | 94 °C/35 s | 58.6 °C/35 s | 72 °C/35 s | 35 |
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Bukovac, A.; Dragičević, K.; Kafka, A.; Orešković, D.; Cesarec-Augustinović, S.; Pećina-Šlaus, N. Decoding the Role of DVL1 in Intracranial Meningioma. Int. J. Mol. Sci. 2021, 22, 11996. https://doi.org/10.3390/ijms222111996
Bukovac A, Dragičević K, Kafka A, Orešković D, Cesarec-Augustinović S, Pećina-Šlaus N. Decoding the Role of DVL1 in Intracranial Meningioma. International Journal of Molecular Sciences. 2021; 22(21):11996. https://doi.org/10.3390/ijms222111996
Chicago/Turabian StyleBukovac, Anja, Katarina Dragičević, Anja Kafka, Darko Orešković, Sanja Cesarec-Augustinović, and Nives Pećina-Šlaus. 2021. "Decoding the Role of DVL1 in Intracranial Meningioma" International Journal of Molecular Sciences 22, no. 21: 11996. https://doi.org/10.3390/ijms222111996