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Article

Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver

1
Department of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China
2
Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
3
School of Pharmacy, Harbin Medical University, Harbin 150000, China
4
School of Pharmaceutical Sciences, Shenzhen Technology University, Shenzhen 518060, China
*
Author to whom correspondence should be addressed.
Academic Editor: Carlo Virginio Agostoni
Int. J. Mol. Sci. 2021, 22(20), 11107; https://doi.org/10.3390/ijms222011107
Received: 11 September 2021 / Revised: 9 October 2021 / Accepted: 11 October 2021 / Published: 14 October 2021
(This article belongs to the Section Molecular Endocrinology and Metabolism)
Atorvastatin ester (Ate) is a structural trim of atorvastatin that can regulate hyperlipidemia. The purpose of this study was to evaluate the lipid-lowering effect of Ate. Male Sprague Dawley (SD) rats were fed a high-fat diet for seven months and used as a hyperlipidemia model. The lipid level and liver function of the hyperlipidemia rats were studied by the levels of TG, TC, LDL, HDL, ALT, and AST in serum after intragastric administration with different doses of Ate. HE staining was used to observe the pathological changes of the rat liver and gastrocnemius muscle. The lipid deposits in the liver of rats were observed by staining with ORO. The genes in the rat liver were sequenced by RNA-sequencing. The results of the RNA-sequencing were further examined by qRT-PCR and western blotting. Biochemical test results indicated that Ate could obviously improve the metabolic disorder and reduce both the ALT and AST levels in serum of the hyperlipidemia rats. Pathological results showed that Ate could improve HFD-induced lipid deposition and had no muscle toxicity. The RNA-sequencing results suggested that Ate affected liver lipid metabolism and cholesterol, metabolism in the hyperlipidemia-model rats may vary via the PPAR-signaling pathway. The western blotting and qRT-PCR results demonstrated the Ate-regulated lipid metabolism in the hyperlipidemia model through the PPAR-signaling pathway and HMGCR expression. In brief, Ate can significantly regulate the blood lipid level of the model rats, which may be achieved by regulating the PPAR-signaling pathway and HMGCR gene expression. View Full-Text
Keywords: atorvastatin ester; hyperlipidemia; RNA-sequencing; PPAR-signaling pathway; gene expression atorvastatin ester; hyperlipidemia; RNA-sequencing; PPAR-signaling pathway; gene expression
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MDPI and ACS Style

Hu, N.; Chen, C.; Wang, J.; Huang, J.; Yao, D.; Li, C. Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver. Int. J. Mol. Sci. 2021, 22, 11107. https://doi.org/10.3390/ijms222011107

AMA Style

Hu N, Chen C, Wang J, Huang J, Yao D, Li C. Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver. International Journal of Molecular Sciences. 2021; 22(20):11107. https://doi.org/10.3390/ijms222011107

Chicago/Turabian Style

Hu, Nan, Chunyun Chen, Jinhui Wang, Jian Huang, Dahong Yao, and Chunli Li. 2021. "Atorvastatin Ester Regulates Lipid Metabolism in Hyperlipidemia Rats via the PPAR-signaling Pathway and HMGCR Expression in the Liver" International Journal of Molecular Sciences 22, no. 20: 11107. https://doi.org/10.3390/ijms222011107

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