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Article

The Formation of the Epiphyseal Bone Plate Occurs via Combined Endochondral and Intramembranous-Like Ossification

1
Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, 33006 Oviedo, Asturias, Spain
2
Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), 33011 Oviedo, Asturias, Spain
3
Department of Pediatrics, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Asturias, Spain
4
Department of Morphology and Cellular Biology, Faculty of Medicine, University of Oviedo, 33006 Oviedo, Asturias, Spain
*
Author to whom correspondence should be addressed.
Á.F.-I. and R.F. contributed equally to this work and should be considered as co-first authors.
Int. J. Mol. Sci. 2021, 22(2), 900; https://doi.org/10.3390/ijms22020900
Received: 14 December 2020 / Revised: 8 January 2021 / Accepted: 15 January 2021 / Published: 18 January 2021
(This article belongs to the Special Issue Osteoblast Differentiation and Activity in Skeletal Diseases)
The formation of the epiphyseal bone plate, the flat bony structure that provides strength and firmness to the growth plate cartilage, was studied in the present study by using light, confocal, and scanning electron microscopy. Results obtained evidenced that this bone tissue is generated by the replacement of the lower portion of the epiphyseal cartilage. However, this process differs considerably from the usual bone tissue formation through endochondral ossification. Osteoblasts deposit bone matrix on remnants of mineralized cartilage matrix that serve as a scaffold, but also on non-mineralized cartilage surfaces and as well as within the perivascular space. These processes occur simultaneously at sites located close to each other, so that, a core of the sheet of bone is established very quickly. Subsequently, thickening and reshaping occurs by appositional growth to generate a dense parallel-fibered bone structurally intermediate between woven and lamellar bone. All these processes occur in close relationship with a cartilage but most of the bone tissue is generated in a manner that may be considered as intramembranous-like. Overall, the findings here reported provide for the first time an accurate description of the tissues and events involved in the formation of the epiphyseal bone plate and gives insight into the complex cellular events underlying bone formation at different sites on the skeleton. View Full-Text
Keywords: bone plate; endochondral ossification; intramembranous ossification; chondrocyte; osteoblast bone plate; endochondral ossification; intramembranous ossification; chondrocyte; osteoblast
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MDPI and ACS Style

Fernández-Iglesias, Á.; Fuente, R.; Gil-Peña, H.; Alonso-Durán, L.; Santos, F.; López, J.M. The Formation of the Epiphyseal Bone Plate Occurs via Combined Endochondral and Intramembranous-Like Ossification. Int. J. Mol. Sci. 2021, 22, 900. https://doi.org/10.3390/ijms22020900

AMA Style

Fernández-Iglesias Á, Fuente R, Gil-Peña H, Alonso-Durán L, Santos F, López JM. The Formation of the Epiphyseal Bone Plate Occurs via Combined Endochondral and Intramembranous-Like Ossification. International Journal of Molecular Sciences. 2021; 22(2):900. https://doi.org/10.3390/ijms22020900

Chicago/Turabian Style

Fernández-Iglesias, Ángela, Rocío Fuente, Helena Gil-Peña, Laura Alonso-Durán, Fernando Santos, and José M. López 2021. "The Formation of the Epiphyseal Bone Plate Occurs via Combined Endochondral and Intramembranous-Like Ossification" International Journal of Molecular Sciences 22, no. 2: 900. https://doi.org/10.3390/ijms22020900

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