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Anti-Aging Physiological Roles of Aryl Hydrocarbon Receptor and Its Dietary Regulators
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The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions

Department of Medicine and Surgery, University of Perugia, 06132 Perugia, Italy
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Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
These authors share senior authorship.
Int. J. Mol. Sci. 2021, 22(2), 757; https://doi.org/10.3390/ijms22020757
Received: 4 December 2020 / Revised: 9 January 2021 / Accepted: 11 January 2021 / Published: 13 January 2021
(This article belongs to the Special Issue Aryl Hydrocarbon Receptor in Biology and Toxicology 2.0)
The aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates numerous cellular responses. Originally investigated in toxicology because of its ability to bind environmental contaminants, AhR has attracted enormous attention in the field of immunology in the last 20 years. In addition, the discovery of endogenous and plant-derived ligands points to AhR also having a crucial role in normal cell physiology. Thus, AhR is emerging as a promiscuous receptor that can mediate either toxic or physiologic effects upon sensing multiple exogenous and endogenous molecules. Within this scenario, several factors appear to contribute to the outcome of gene transcriptional regulation by AhR, including the nature of the ligand as such and its further metabolism by AhR-induced enzymes, the local tissue microenvironment, and the presence of coregulators or specific transcription factors in the cell. Here, we review the current knowledge on the array of transcription factors and coregulators that, by interacting with AhR, tune its transcriptional activity in response to endogenous and exogenous ligands. View Full-Text
Keywords: arylhydrocarbon receptor (AhR); transcription factors; coregulators; nuclear coactivator; immune regulation arylhydrocarbon receptor (AhR); transcription factors; coregulators; nuclear coactivator; immune regulation
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MDPI and ACS Style

Gargaro, M.; Scalisi, G.; Manni, G.; Mondanelli, G.; Grohmann, U.; Fallarino, F. The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions. Int. J. Mol. Sci. 2021, 22, 757. https://doi.org/10.3390/ijms22020757

AMA Style

Gargaro M, Scalisi G, Manni G, Mondanelli G, Grohmann U, Fallarino F. The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions. International Journal of Molecular Sciences. 2021; 22(2):757. https://doi.org/10.3390/ijms22020757

Chicago/Turabian Style

Gargaro, Marco; Scalisi, Giulia; Manni, Giorgia; Mondanelli, Giada; Grohmann, Ursula; Fallarino, Francesca. 2021. "The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions" Int. J. Mol. Sci. 22, no. 2: 757. https://doi.org/10.3390/ijms22020757

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