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How the AHR Became Important in Cancer: The Role of Chronically Active AHR in Cancer Aggression
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AhR and Cancer: From Gene Profiling to Targeted Therapy

1
CNRS (Centre National de la Recherche Scientifique), IGDR (Institut de Génétique et Développement de Rennes), UMR6290, University Rennes, F-35000 Rennes, France
2
Department of Molecular Genetics and Genomics, Hospital University of Rennes (CHU Rennes), F-35000 Rennes, France
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the work.
Int. J. Mol. Sci. 2021, 22(2), 752; https://doi.org/10.3390/ijms22020752
Received: 6 November 2020 / Revised: 4 January 2021 / Accepted: 8 January 2021 / Published: 13 January 2021
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that has been shown to be an essential regulator of a broad spectrum of biological activities required for maintaining the body’s vital functions. AhR also plays a critical role in tumorigenesis. Its role in cancer is complex, encompassing both pro- and anti-tumorigenic activities. Its level of expression and activity are specific to each tumor and patient, increasing the difficulty of understanding the activating or inhibiting roles of AhR ligands. We explored the role of AhR in tumor cell lines and patients using genomic data sets and discuss the extent to which AhR can be considered as a therapeutic target. View Full-Text
Keywords: AhR transcription factor; expression; cancer; targeted therapy AhR transcription factor; expression; cancer; targeted therapy
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MDPI and ACS Style

Paris, A.; Tardif, N.; Galibert, M.-D.; Corre, S. AhR and Cancer: From Gene Profiling to Targeted Therapy. Int. J. Mol. Sci. 2021, 22, 752. https://doi.org/10.3390/ijms22020752

AMA Style

Paris A, Tardif N, Galibert M-D, Corre S. AhR and Cancer: From Gene Profiling to Targeted Therapy. International Journal of Molecular Sciences. 2021; 22(2):752. https://doi.org/10.3390/ijms22020752

Chicago/Turabian Style

Paris, Anaïs; Tardif, Nina; Galibert, Marie-Dominique; Corre, Sébastien. 2021. "AhR and Cancer: From Gene Profiling to Targeted Therapy" Int. J. Mol. Sci. 22, no. 2: 752. https://doi.org/10.3390/ijms22020752

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