Next Article in Journal
Novel Tyrosine Kinase Targets in Urothelial Carcinoma
Previous Article in Journal
Involvement of SUT1 and SUT2 Sugar Transporters in the Impairment of Sugar Transport and Changes in Phloem Exudate Contents in Phytoplasma-Infected Plants
Previous Article in Special Issue
Role of microRNA and Oxidative Stress in Influenza A Virus Pathogenesis
Open AccessReview

Field Cancerization in NSCLC: A New Perspective on MicroRNAs in Macrophage Polarization

1
Research Center for Functional Genomics, Biomedicine and Translational Medicine, The “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
2
Department of Morphological Sciences, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
3
Department of Functional Sciences, Immunology and Allergology, The “Iuliu Hatieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
4
The Functional Genomics Department, The Oncology Institute “Prof. Dr. Ion Chiricuta”, 400015 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(2), 746; https://doi.org/10.3390/ijms22020746
Received: 13 December 2020 / Revised: 7 January 2021 / Accepted: 8 January 2021 / Published: 13 January 2021
Lung cancer is currently the first cause of cancer-related death. The major lung cancer subtype is non-small cell lung cancers (NSCLC), which accounts for approximatively 85% of cases. The major carcinogenic associated with lung cancer is tobacco smoke, which produces long-lasting and progressive damage to the respiratory tract. The progressive and diffuse alterations that occur in the respiratory tract of patients with cancer and premalignant lesions have been described as field cancerization. At the level of tumor cells, adjacent tumor microenvironment (TME) and cancerized field are taking place dynamic interactions through direct cell-to-cell communication or through extracellular vesicles. These molecular messages exchanged between tumor and nontumor cells are represented by proteins, noncoding RNAs (ncRNAs) and microRNAs (miRNAs). In this paper, we analyze the miRNA roles in the macrophage polarization at the level of TME and cancerized field in NSCLC. Identifying molecular players that can influence the phenotypic states at the level of malignant cells, tumor microenvironment and cancerized field can provide us new insights into tumor regulatory mechanisms that can be further modulated to restore the immunogenic capacity of the TME. This approach could revert alterations in the cancerized field and could enhance currently available therapy approaches. View Full-Text
Keywords: lung cancer; field cancerization; tumor microenvironment; macrophage polarization; miRNA lung cancer; field cancerization; tumor microenvironment; macrophage polarization; miRNA
Show Figures

Figure 1

MDPI and ACS Style

Pirlog, R.; Cismaru, A.; Nutu, A.; Berindan-Neagoe, I. Field Cancerization in NSCLC: A New Perspective on MicroRNAs in Macrophage Polarization. Int. J. Mol. Sci. 2021, 22, 746. https://doi.org/10.3390/ijms22020746

AMA Style

Pirlog R, Cismaru A, Nutu A, Berindan-Neagoe I. Field Cancerization in NSCLC: A New Perspective on MicroRNAs in Macrophage Polarization. International Journal of Molecular Sciences. 2021; 22(2):746. https://doi.org/10.3390/ijms22020746

Chicago/Turabian Style

Pirlog, Radu; Cismaru, Andrei; Nutu, Andreea; Berindan-Neagoe, Ioana. 2021. "Field Cancerization in NSCLC: A New Perspective on MicroRNAs in Macrophage Polarization" Int. J. Mol. Sci. 22, no. 2: 746. https://doi.org/10.3390/ijms22020746

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop