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Review

Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them

1
Institute for Pharmacy and Molecular Biotechnology (IPMB), Ruprecht Karls University Heidelberg, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
2
Max-Planck-Institute for Medical Research, Jahnstr. 29, 69120 Heidelberg, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Aamir Ahmad
Int. J. Mol. Sci. 2021, 22(19), 10577; https://doi.org/10.3390/ijms221910577
Received: 10 September 2021 / Revised: 24 September 2021 / Accepted: 26 September 2021 / Published: 30 September 2021
(This article belongs to the Section Molecular Biology)
Glycan–lectin interactions play an essential role in different cellular processes. One of their main functions is involvement in the immune response to pathogens or inflammation. However, cancer cells and viruses have adapted to avail themselves of these interactions. By displaying specific glycosylation structures, they are able to bind to lectins, thus promoting pathogenesis. While glycan–lectin interactions promote tumor progression, metastasis, and/or chemoresistance in cancer, in viral infections they are important for viral entry, release, and/or immune escape. For several years now, a growing number of investigations have been devoted to clarifying the role of glycan–lectin interactions in cancer and viral infections. Various overviews have already summarized and highlighted their findings. In this review, we consider the interactions of the lectins MGL, DC-SIGN, selectins, and galectins in both cancer and viral infections together. A possible transfer of ways to target and disrupt them might lead to new therapeutic approaches in different pathological backgrounds. View Full-Text
Keywords: cancer; DC-SIGN; galectins; glycosylation; lectins; MGL; selectins; virus cancer; DC-SIGN; galectins; glycosylation; lectins; MGL; selectins; virus
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MDPI and ACS Style

Kremsreiter, S.M.; Kroell, A.-S.H.; Weinberger, K.; Boehm, H. Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them. Int. J. Mol. Sci. 2021, 22, 10577. https://doi.org/10.3390/ijms221910577

AMA Style

Kremsreiter SM, Kroell A-SH, Weinberger K, Boehm H. Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them. International Journal of Molecular Sciences. 2021; 22(19):10577. https://doi.org/10.3390/ijms221910577

Chicago/Turabian Style

Kremsreiter, Stefanie M., Ann-Sophie H. Kroell, Katharina Weinberger, and Heike Boehm. 2021. "Glycan–Lectin Interactions in Cancer and Viral Infections and How to Disrupt Them" International Journal of Molecular Sciences 22, no. 19: 10577. https://doi.org/10.3390/ijms221910577

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