Next Article in Journal
Metformin Affects Olaparib Sensitivity through Induction of Apoptosis in Epithelial Ovarian Cancer Cell Lines
Next Article in Special Issue
The Roles of Carbohydrate Response Element Binding Protein in the Relationship between Carbohydrate Intake and Diseases
Previous Article in Journal
Vitamin D and COVID-19: An Overview of Recent Evidence
Previous Article in Special Issue
Perinatal High-Fat Diet Influences Ozone-Induced Responses on Pulmonary Oxidant Status and the Molecular Control of Mitophagy in Female Rat Offspring
Article

The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression

1
The Laboratory of Physiological Genetics, The Institute of Cytology and Genetics, 630090 Novosibirsk, Russia
2
The Institute of Molecular and Cellular Biology, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Academic Editors: Giovanna Bermano and Hervé Guillou
Int. J. Mol. Sci. 2021, 22(19), 10561; https://doi.org/10.3390/ijms221910561
Received: 31 May 2021 / Revised: 14 August 2021 / Accepted: 25 September 2021 / Published: 29 September 2021
(This article belongs to the Special Issue Nutrient-Gene Interactions)
The preference for high-calorie foods depends on sex and contributes to obesity development. Fibroblast growth factor 21 (FGF21) beneficially affects taste preferences and obesity, but its action has mainly been studied in males. The aim of this study was to compare the effects of FGF21 on food preferences and glucose and lipid metabolism in C57Bl/6J male and female mice with diet-induced obesity. Mice were injected with FGF21 or vehicle for 7 days. Body weight, choice between standard (SD) and high-fat (HFD) diets, blood parameters, and gene expression in white (WAT) and brown (BAT) adipose tissues, liver, muscles, and the hypothalamus were assessed. Compared to males, females had a greater preference for HFD; less WAT; lower levels of cholesterol, glucose, and insulin; and higher expression of Fgf21, Insr, Ppara, Pgc1, Acca and Accb in the liver and Dio2 in BAT. FGF21 administration decreased adiposity; blood levels of cholesterol, glucose, and insulin; hypothalamic Agrp expression, increased SD intake, decreased HFD intake independently of sex, and increased WAT expression of Pparg, Lpl and Lipe only in females. Thus, FGF21 administration beneficially affected mice of both sexes despite obesity-associated sex differences in metabolic characteristics, and it induced female-specific activation of gene expression in WAT. View Full-Text
Keywords: FGF21; mice; obesity; food preferences; sex differences; gene expression FGF21; mice; obesity; food preferences; sex differences; gene expression
Show Figures

Figure 1

MDPI and ACS Style

Makarova, E.; Kazantseva, A.; Dubinina, A.; Jakovleva, T.; Balybina, N.; Baranov, K.; Bazhan, N. The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression. Int. J. Mol. Sci. 2021, 22, 10561. https://doi.org/10.3390/ijms221910561

AMA Style

Makarova E, Kazantseva A, Dubinina A, Jakovleva T, Balybina N, Baranov K, Bazhan N. The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression. International Journal of Molecular Sciences. 2021; 22(19):10561. https://doi.org/10.3390/ijms221910561

Chicago/Turabian Style

Makarova, Elena, Antonina Kazantseva, Anastasia Dubinina, Tatiana Jakovleva, Natalia Balybina, Konstantin Baranov, and Nadezhda Bazhan. 2021. "The Same Metabolic Response to FGF21 Administration in Male and Female Obese Mice Is Accompanied by Sex-Specific Changes in Adipose Tissue Gene Expression" International Journal of Molecular Sciences 22, no. 19: 10561. https://doi.org/10.3390/ijms221910561

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop