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Review

Vitamin D and COVID-19: An Overview of Recent Evidence

Monash Centre for Health Research and Implementation (MCHRI), Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC 3168, Australia
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Academic Editors: Andrzej Slominski and Frank De Gruijl
Int. J. Mol. Sci. 2021, 22(19), 10559; https://doi.org/10.3390/ijms221910559
Received: 6 August 2021 / Revised: 23 September 2021 / Accepted: 23 September 2021 / Published: 29 September 2021
The novel coronavirus severe acute respiratory syndrome (SARS-CoV-2) has progressed rapidly from an outbreak to a global pandemic, with new variants rapidly emerging. Coronavirus disease 2019 (COVID-19), the disease resulting from SARS-CoV-2 infection, can lead to multiorgan damage. Due to the extremely contagious and fatal nature of the virus, it has been a priority of medical research to find effective means of treatment. Amid this search, the role of vitamin D in modulating various aspects of the innate and adaptive immune system has been discussed. This review aims to consolidate the research surrounding the role of vitamin D in the treatment and prevention of COVID-19. While there are some conflicting results reported, the consensus is that vitamin D has a host of immunomodulatory effects which may be beneficial in the context of COVID-19 and that low levels of vitamin D can result in dysfunction of crucial antimicrobial effects, potentially contributing to poor prognosis. Studies also show that the effects of low vitamin D can be mitigated via supplementation, although the benefits of vitamin D supplementation in the treatment of COVID-19 remain controversial. View Full-Text
Keywords: vitamin D; coronavirus; COVID-19; SARS-CoV-2; immunity; infection; review vitamin D; coronavirus; COVID-19; SARS-CoV-2; immunity; infection; review
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MDPI and ACS Style

Ghelani, D.; Alesi, S.; Mousa, A. Vitamin D and COVID-19: An Overview of Recent Evidence. Int. J. Mol. Sci. 2021, 22, 10559. https://doi.org/10.3390/ijms221910559

AMA Style

Ghelani D, Alesi S, Mousa A. Vitamin D and COVID-19: An Overview of Recent Evidence. International Journal of Molecular Sciences. 2021; 22(19):10559. https://doi.org/10.3390/ijms221910559

Chicago/Turabian Style

Ghelani, Drishti, Simon Alesi, and Aya Mousa. 2021. "Vitamin D and COVID-19: An Overview of Recent Evidence" International Journal of Molecular Sciences 22, no. 19: 10559. https://doi.org/10.3390/ijms221910559

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