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Review

Impaired Mitophagy in Neurons and Glial Cells during Aging and Age-Related Disorders

Research Center of Neurology, Department for Brain Research, 125367 Moscow, Russia
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Author to whom correspondence should be addressed.
Academic Editors: Sergei B. Seredenin, Tatiana A. Gudasheva and Yulia V. Vakhitova
Int. J. Mol. Sci. 2021, 22(19), 10251; https://doi.org/10.3390/ijms221910251
Received: 5 August 2021 / Revised: 18 September 2021 / Accepted: 22 September 2021 / Published: 23 September 2021
(This article belongs to the Special Issue Molecular Mechanisms and Pharmacological Targeting of Neuroprotection)
Aging is associated with a decline in cognitive function, which can partly be explained by the accumulation of damage to the brain cells over time. Neurons and glia undergo morphological and ultrastructure changes during aging. Over the past several years, it has become evident that at the cellular level, various hallmarks of an aging brain are closely related to mitophagy. The importance of mitochondria quality and quantity control through mitophagy is highlighted by the contribution that defects in mitochondria–autophagy crosstalk make to aging and age-related diseases. In this review, we analyze some of the more recent findings regarding the study of brain aging and neurodegeneration in the context of mitophagy. We discuss the data on the dynamics of selective autophagy in neurons and glial cells during aging and in the course of neurodegeneration, focusing on three mechanisms of mitophagy: non-receptor-mediated mitophagy, receptor-mediated mitophagy, and transcellular mitophagy. We review the role of mitophagy in neuronal/glial homeostasis and in the molecular pathogenesis of neurodegenerative disorders, such as Parkinson’s disease, Alzheimer’s disease, and other disorders. Common mechanisms of aging and neurodegeneration that are related to different mitophagy pathways provide a number of promising targets for potential therapeutic agents. View Full-Text
Keywords: mitophagy; aging; neurodegeneration; Parkinson’s disease; Alzheimer’s disease mitophagy; aging; neurodegeneration; Parkinson’s disease; Alzheimer’s disease
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MDPI and ACS Style

Sukhorukov, V.; Voronkov, D.; Baranich, T.; Mudzhiri, N.; Magnaeva, A.; Illarioshkin, S. Impaired Mitophagy in Neurons and Glial Cells during Aging and Age-Related Disorders. Int. J. Mol. Sci. 2021, 22, 10251. https://doi.org/10.3390/ijms221910251

AMA Style

Sukhorukov V, Voronkov D, Baranich T, Mudzhiri N, Magnaeva A, Illarioshkin S. Impaired Mitophagy in Neurons and Glial Cells during Aging and Age-Related Disorders. International Journal of Molecular Sciences. 2021; 22(19):10251. https://doi.org/10.3390/ijms221910251

Chicago/Turabian Style

Sukhorukov, Vladimir, Dmitry Voronkov, Tatiana Baranich, Natalia Mudzhiri, Alina Magnaeva, and Sergey Illarioshkin. 2021. "Impaired Mitophagy in Neurons and Glial Cells during Aging and Age-Related Disorders" International Journal of Molecular Sciences 22, no. 19: 10251. https://doi.org/10.3390/ijms221910251

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