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Volume 22
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10.3390/ijms22189782
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Review

Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review

by
Maria Greabu
1,
Silviu Constantin Badoiu
2,3,*,
Iulia-Ioana Stanescu-Spinu
1,*,
Daniela Miricescu
1,
Alexandra Ripszky Totan
1,
Silvia Elena Badoiu
4,
Michel Costagliola
5 and
Viorel Jinga
6
1
Department of Biochemistry, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
2
Department of Anatomy and Embriology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
3
Department of Plastic and Reconstructive Surgery, Life Memorial Hospital, 365 Grivitei Street, 010719 Bucharest, Romania
4
Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd, 050474 Bucharest, Romania
5
Department of Plastic and Reconstructive Surgery, Faculté de Médicine Toulouse-Rangueil 3, Université Toulouse III-Paul Sabatier, Rue de Languedoc, CEDEX 04, 31000 Toulouse, France
6
Department of Urology–Clinical Hospital Prof. Dr. Th. Burghele, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 030167 Bucharest, Romania
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(18), 9782; https://doi.org/10.3390/ijms22189782
Submission received: 30 July 2021 / Revised: 3 September 2021 / Accepted: 8 September 2021 / Published: 10 September 2021
(This article belongs to the Special Issue Molecular and Biochemical Aspects in Burns)
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Abstract

It has become widely accepted that insulin resistance and glucose hypermetabolism can be linked to acute pathologies, such as burn injury, severe trauma, or sepsis. Severe burns can determine a significant increase in catabolism, having an important effect on glucose metabolism and on muscle protein metabolism. It is imperative to acknowledge that these alterations can lead to increased mortality through organ failure, even when the patients survive the initial trauma caused by the burn. By limiting the peripheral use of glucose with consequent hyperglycemia, insulin resistance determines compensatory increased levels of insulin in plasma. However, the significant alterations in cellular metabolism lead to a lack of response to insulin’s anabolic functions, as well as to a decrease in its cytoprotective role. In the end, via pathological insulin signaling associated with increased liver gluconeogenesis, elevated levels of glucose are detected in the blood. Several cellular mechanisms have been incriminated in the development of insulin resistance in burns. In this context, the main aim of this review article is to summarize some of the drugs that might interfere with insulin resistance in burns, taking into consideration that such an approach can significantly improve the prognosis of the burned patient.
Keywords: burns; insulin resistance; insulin signaling pathway; β blockers; statins; thiazolidinediones; metformin burns; insulin resistance; insulin signaling pathway; β blockers; statins; thiazolidinediones; metformin

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MDPI and ACS Style

Greabu, M.; Badoiu, S.C.; Stanescu-Spinu, I.-I.; Miricescu, D.; Totan, A.R.; Badoiu, S.E.; Costagliola, M.; Jinga, V. Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review. Int. J. Mol. Sci. 2021, 22, 9782. https://doi.org/10.3390/ijms22189782

AMA Style

Greabu M, Badoiu SC, Stanescu-Spinu I-I, Miricescu D, Totan AR, Badoiu SE, Costagliola M, Jinga V. Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review. International Journal of Molecular Sciences. 2021; 22(18):9782. https://doi.org/10.3390/ijms22189782

Chicago/Turabian Style

Greabu, Maria, Silviu Constantin Badoiu, Iulia-Ioana Stanescu-Spinu, Daniela Miricescu, Alexandra Ripszky Totan, Silvia Elena Badoiu, Michel Costagliola, and Viorel Jinga. 2021. "Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review" International Journal of Molecular Sciences 22, no. 18: 9782. https://doi.org/10.3390/ijms22189782

APA Style

Greabu, M., Badoiu, S. C., Stanescu-Spinu, I.-I., Miricescu, D., Totan, A. R., Badoiu, S. E., Costagliola, M., & Jinga, V. (2021). Drugs Interfering with Insulin Resistance and Their Influence on the Associated Hypermetabolic State in Severe Burns: A Narrative Review. International Journal of Molecular Sciences, 22(18), 9782. https://doi.org/10.3390/ijms22189782

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