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Review

Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis

1
Graduate Institute of Basic Medical Science, China Medical University, Taichung 40402, Taiwan
2
Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei City 111, Taiwan
3
School of Medicine, China Medical University, Taichung 40402, Taiwan
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Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung 40447, Taiwan
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Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
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Department of Medical Research, Chung Shan Medical University Hospital, Taichung 40201, Taiwan
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Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan
8
Chinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan
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Department of Biotechnology, College of Health Science, Asia University, Taichung 41354, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Int. J. Mol. Sci. 2021, 22(17), 9435; https://doi.org/10.3390/ijms22179435
Received: 28 July 2021 / Revised: 25 August 2021 / Accepted: 27 August 2021 / Published: 30 August 2021
(This article belongs to the Special Issue Osteoporosis: From Molecular Mechanisms to Therapies 3.0)
Osteoblasts and osteoclasts are major cellular components in the bone microenvironment and they play a key role in the bone turnover cycle. Many risk factors interfere with this cycle and contribute to bone-wasting diseases that progressively destroy bone and markedly reduce quality of life. Melatonin (N-acetyl-5-methoxy-tryptamine) has demonstrated intriguing therapeutic potential in the bone microenvironment, with reported effects that include the regulation of bone metabolism, acceleration of osteoblastogenesis, inhibition of osteoclastogenesis and the induction of apoptosis in mature osteoclasts, as well as the suppression of osteolytic bone metastasis. This review aims to shed light on molecular and clinical evidence that points to possibilities of melatonin for the treatment of both osteoporosis and osteolytic bone metastasis. It appears that the therapeutic qualities of melatonin supplementation may enable existing antiresorptive osteoporotic drugs to treat osteolytic metastasis. View Full-Text
Keywords: apoptosis; bone mass protection; bone metastasis; immunomodulation; melatonin; osteoclastogenesis; osteoclasts; osteoporosis apoptosis; bone mass protection; bone metastasis; immunomodulation; melatonin; osteoclastogenesis; osteoclasts; osteoporosis
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MDPI and ACS Style

MacDonald, I.J.; Tsai, H.-C.; Chang, A.-C.; Huang, C.-C.; Yang, S.-F.; Tang, C.-H. Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis. Int. J. Mol. Sci. 2021, 22, 9435. https://doi.org/10.3390/ijms22179435

AMA Style

MacDonald IJ, Tsai H-C, Chang A-C, Huang C-C, Yang S-F, Tang C-H. Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis. International Journal of Molecular Sciences. 2021; 22(17):9435. https://doi.org/10.3390/ijms22179435

Chicago/Turabian Style

MacDonald, Iona J., Hsiao-Chi Tsai, An-Chen Chang, Chien-Chung Huang, Shun-Fa Yang, and Chih-Hsin Tang. 2021. "Melatonin Inhibits Osteoclastogenesis and Osteolytic Bone Metastasis: Implications for Osteoporosis" International Journal of Molecular Sciences 22, no. 17: 9435. https://doi.org/10.3390/ijms22179435

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