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Article

Screening Anti-Inflammatory Effects of Flavanones Solutions

by
Paola Bustos-Salgado
1,
Berenice Andrade-Carrera
2,
Valeri Domínguez-Villegas
2,
Natalia Díaz-Garrido
3,4,5,
María J. Rodríguez-Lagunas
3,6,
Josefa Badía
3,4,5,
Laura Baldomà
3,4,5,
Mireia Mallandrich
1,
Ana Calpena-Campmany
1,* and
María Luisa Garduño-Ramírez
7,*
1
Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Science, University of Barcelona, Av. Joan XXIII 29-31, 08028 Barcelona, Spain
2
Faculty of Chemical Sciences and Engineering, Autonomous University of the State of Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico
3
Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
4
Institute of Biomedicine, University of Barcelona (IBUB), 08028 Barcelona, Spain
5
Research Institute Sant Joan De Déu (IR-SJD), University of Barcelona (IBUB), 08028 Barcelona, Spain
6
Institute of Research in Food Nutrition and Safety, University of Barcelona (INSA-UB), 08921 Santa Coloma de Gramenet, Spain
7
Center for Chemical Research, Institute for Research Basic and Applied Sciences, Autonomous University of the State of Morelos, Av. Universidad 1001, Cuernavaca 62209, Mexico
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(16), 8878; https://doi.org/10.3390/ijms22168878
Submission received: 26 July 2021 / Revised: 15 August 2021 / Accepted: 16 August 2021 / Published: 18 August 2021
(This article belongs to the Special Issue Efficacy of Flavonoids in Chronic Diseases)
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Abstract

There are a large number of remedies in traditional medicine focused on relieving pain and inflammation. Flavanones have been a potential source in the search for leading compounds and biologically active components, and they have been the focus of much research and development in recent years. Eysenhardtia platycarpa is used in traditional medicine for the treatment of kidney diseases, bladder infections, and diabetes mellitus. Many compounds have been isolated from this plant, such as flavones, flavanones, phenolic compounds, triterpenoid acids, chalcones, sugars, and fatty acids, among others. In this paper, natural flavanone 1 (extracted from Eysenhardtia platycarpa) as lead compound and flavanones 1a–1d as its structural analogues were screened for anti-inflammatory activity using Molinspiration® and PASS Online in a computational study. The hydro alcoholic solutions (FS) of flavanones 1, 1a–1d (FS1, FS1a–FS1d) were also assayed to investigate their in vivo anti-inflammatory cutaneous effect using two experimental models, a rat ear edema induced by arachidonic acid (AA) and a mouse ear edema induced by 12-O-tetradecanoylphorbol acetate (TPA). Histological studies and analysis of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6 were also assessed in AA-inflamed rat ear tissue. The results showed that the flavanone hydro alcoholic solutions (FS) caused edema inhibition in both evaluated models. This study suggests that the evaluated flavanones will be effective when used in the future in skin pathologies with inflammation, with the results showing 1b and 1d to be the best.
Keywords: flavanones; Eysenhardtia platycarpa; in vivo anti-inflammatory activity; cytokines flavanones; Eysenhardtia platycarpa; in vivo anti-inflammatory activity; cytokines

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MDPI and ACS Style

Bustos-Salgado, P.; Andrade-Carrera, B.; Domínguez-Villegas, V.; Díaz-Garrido, N.; Rodríguez-Lagunas, M.J.; Badía, J.; Baldomà, L.; Mallandrich, M.; Calpena-Campmany, A.; Garduño-Ramírez, M.L. Screening Anti-Inflammatory Effects of Flavanones Solutions. Int. J. Mol. Sci. 2021, 22, 8878. https://doi.org/10.3390/ijms22168878

AMA Style

Bustos-Salgado P, Andrade-Carrera B, Domínguez-Villegas V, Díaz-Garrido N, Rodríguez-Lagunas MJ, Badía J, Baldomà L, Mallandrich M, Calpena-Campmany A, Garduño-Ramírez ML. Screening Anti-Inflammatory Effects of Flavanones Solutions. International Journal of Molecular Sciences. 2021; 22(16):8878. https://doi.org/10.3390/ijms22168878

Chicago/Turabian Style

Bustos-Salgado, Paola, Berenice Andrade-Carrera, Valeri Domínguez-Villegas, Natalia Díaz-Garrido, María J. Rodríguez-Lagunas, Josefa Badía, Laura Baldomà, Mireia Mallandrich, Ana Calpena-Campmany, and María Luisa Garduño-Ramírez. 2021. "Screening Anti-Inflammatory Effects of Flavanones Solutions" International Journal of Molecular Sciences 22, no. 16: 8878. https://doi.org/10.3390/ijms22168878

APA Style

Bustos-Salgado, P., Andrade-Carrera, B., Domínguez-Villegas, V., Díaz-Garrido, N., Rodríguez-Lagunas, M. J., Badía, J., Baldomà, L., Mallandrich, M., Calpena-Campmany, A., & Garduño-Ramírez, M. L. (2021). Screening Anti-Inflammatory Effects of Flavanones Solutions. International Journal of Molecular Sciences, 22(16), 8878. https://doi.org/10.3390/ijms22168878

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