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Volume 22
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10.3390/ijms22168825
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Article

Retinoprotective Effects of PACAP Eye Drops in Microbead-Induced Glaucoma Model in Rats

by
Edina Szabo
1,
Evelin Patko
1,
Alexandra Vaczy
1,
Dorottya Molitor
1,
Adrienne Csutak
2,
Gabor Toth
3,
Dora Reglodi
1,4 and
Tamas Atlasz
1,4,5,*
1
Department of Anatomy, MTA-PTE PACAP Research Team, University of Pecs Medical School, 7624 Pecs, Hungary
2
Department of Ophthalmology, Clinical Centre, University of Pecs Medical School, 7632 Pecs, Hungary
3
Department of Medical Chemistry, Faculty of Medicine, University of Szeged, 6720 Szeged, Hungary
4
Szentagothai Research Center, University of Pecs, 7624 Pecs, Hungary
5
Department of Sportbiology, University of Pecs, 7624 Pecs, Hungary
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(16), 8825; https://doi.org/10.3390/ijms22168825
Submission received: 15 July 2021 / Revised: 9 August 2021 / Accepted: 13 August 2021 / Published: 17 August 2021
(This article belongs to the Special Issue Cytoprotective Effects of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) and Related Peptides)
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Abstract

Glaucoma is associated with increased intraocular pressure (IOP), causing the apoptosis of retinal ganglion cells (RGCs) and the loss of their axons leading to blindness. Pituitary adenylate cyclase activating polypeptide (PACAP) is neuroprotective in several neural injuries, including retinopathies. The aim of this study was to investigate the effects of PACAP1-38 eye drops in a model of glaucoma. IOP was elevated bilaterally by injections of microbeads to block the aqueous humor outflow. The control groups received the same volume of saline. Animals were treated with PACAP1-38 (1 µg/drop, 3 × 1 drop/day) or vehicle for 4 weeks starting one day after the injections. Retinal morphology by histology and optical coherence tomography, function by electroretinography, and IOP changes were analyzed. Animals were sacrificed 8 weeks after the injections. Microbeads injections induced a significant increase in the IOP, while PACAP1-38 treatment lowered it to normal levels (~10 mmHg). Significant retinal degeneration and functional impairment were observed in the microbead-injected group without PACAP1-38 treatment. In the microbeads + PACAP1-38 group, the retinal morphology and functionality were close to the normal values. In summary, our results show that PACAP1-38, given in form of eye drops, is neuroprotective in glaucoma, providing the basis for potential future therapeutic administration.
Keywords: glaucoma; PACAP; eye drops; protection; intraocular pressure glaucoma; PACAP; eye drops; protection; intraocular pressure

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MDPI and ACS Style

Szabo, E.; Patko, E.; Vaczy, A.; Molitor, D.; Csutak, A.; Toth, G.; Reglodi, D.; Atlasz, T. Retinoprotective Effects of PACAP Eye Drops in Microbead-Induced Glaucoma Model in Rats. Int. J. Mol. Sci. 2021, 22, 8825. https://doi.org/10.3390/ijms22168825

AMA Style

Szabo E, Patko E, Vaczy A, Molitor D, Csutak A, Toth G, Reglodi D, Atlasz T. Retinoprotective Effects of PACAP Eye Drops in Microbead-Induced Glaucoma Model in Rats. International Journal of Molecular Sciences. 2021; 22(16):8825. https://doi.org/10.3390/ijms22168825

Chicago/Turabian Style

Szabo, Edina, Evelin Patko, Alexandra Vaczy, Dorottya Molitor, Adrienne Csutak, Gabor Toth, Dora Reglodi, and Tamas Atlasz. 2021. "Retinoprotective Effects of PACAP Eye Drops in Microbead-Induced Glaucoma Model in Rats" International Journal of Molecular Sciences 22, no. 16: 8825. https://doi.org/10.3390/ijms22168825

APA Style

Szabo, E., Patko, E., Vaczy, A., Molitor, D., Csutak, A., Toth, G., Reglodi, D., & Atlasz, T. (2021). Retinoprotective Effects of PACAP Eye Drops in Microbead-Induced Glaucoma Model in Rats. International Journal of Molecular Sciences, 22(16), 8825. https://doi.org/10.3390/ijms22168825

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