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Article

Kidney Response to Chemotherapy-Induced Heart Failure: mRNA Analysis in Normotensive and Ren-2 Transgenic Hypertensive Rats

by
Šárka Jíchová
1,
Olga Gawryś
2,
Elżbieta Kompanowska-Jezierska
2,
Janusz Sadowski
2,
Vojtěch Melenovský
3,
Lenka Hošková
3,
Luděk Červenka
1,4,
Petr Kala
1,4,5,
Josef Veselka
5 and
Věra Čertíková Chábová
6,*
1
Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
2
Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, PL02-106 Warsaw, Poland
3
Department of Cardiology, Institute for Clinical and Experimental Medicine, 14021 Prague, Czech Republic
4
Department of Pathophysiology, 2nd Faculty of Medicine, Charles University, 15006 Prague, Czech Republic
5
Department of Cardiology, University Hospital Motol and 2nd Faculty of Medicine, Charles University, 15006 Prague, Czech Republic
6
Department of Nephrology, 1st Faculty of Medicine, Charles University, 12108 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(16), 8475; https://doi.org/10.3390/ijms22168475
Submission received: 30 April 2021 / Revised: 2 August 2021 / Accepted: 3 August 2021 / Published: 6 August 2021
(This article belongs to the Special Issue Mechanisms of Cardiovascular Disease: Molecular Perspective)
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Abstract

The aim of the present study was to perform kidney messenger ribonucleic acid (mRNA) analysis in normotensive, Hannover Sprague–Dawley (HanSD) rats and hypertensive, Ren-2 renin transgenic rats (TGR) after doxorubicin-induced heart failure (HF) with specific focus on genes that are implicated in the pathophysiology of HF-associated cardiorenal syndrome. We found that in both strains renin and angiotensin-converting enzyme mRNA expressions were upregulated indicating that the vasoconstrictor axis of the renin–angiotensin system was activated. We found that pre-proendothelin-1, endothelin-converting enzyme type 1 and endothelin type A receptor mRNA expressions were upregulated in HanSD rats, but not in TGR, suggesting the activation of endothelin system in HanSD rats, but not in TGR. We found that mRNA expression of cytochrome P-450 subfamily 2C23 was downregulated in TGR and not in HanSD rats, suggesting the deficiency in the intrarenal cytochrome P450-dependent pathway of arachidonic acid metabolism in TGR. These results should be the basis for future studies evaluating the pathophysiology of cardiorenal syndrome secondary to chemotherapy-induced HF in order to potentially develop new therapeutic approaches.
Keywords: chemotherapy-induced heart failure; doxorubicin; hypertension; kidney; renin-angiotensin-aldosterone system; endothelin system; cytochrome P-450; renal adrenergic system chemotherapy-induced heart failure; doxorubicin; hypertension; kidney; renin-angiotensin-aldosterone system; endothelin system; cytochrome P-450; renal adrenergic system

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MDPI and ACS Style

Jíchová, Š.; Gawryś, O.; Kompanowska-Jezierska, E.; Sadowski, J.; Melenovský, V.; Hošková, L.; Červenka, L.; Kala, P.; Veselka, J.; Čertíková Chábová, V. Kidney Response to Chemotherapy-Induced Heart Failure: mRNA Analysis in Normotensive and Ren-2 Transgenic Hypertensive Rats. Int. J. Mol. Sci. 2021, 22, 8475. https://doi.org/10.3390/ijms22168475

AMA Style

Jíchová Š, Gawryś O, Kompanowska-Jezierska E, Sadowski J, Melenovský V, Hošková L, Červenka L, Kala P, Veselka J, Čertíková Chábová V. Kidney Response to Chemotherapy-Induced Heart Failure: mRNA Analysis in Normotensive and Ren-2 Transgenic Hypertensive Rats. International Journal of Molecular Sciences. 2021; 22(16):8475. https://doi.org/10.3390/ijms22168475

Chicago/Turabian Style

Jíchová, Šárka, Olga Gawryś, Elżbieta Kompanowska-Jezierska, Janusz Sadowski, Vojtěch Melenovský, Lenka Hošková, Luděk Červenka, Petr Kala, Josef Veselka, and Věra Čertíková Chábová. 2021. "Kidney Response to Chemotherapy-Induced Heart Failure: mRNA Analysis in Normotensive and Ren-2 Transgenic Hypertensive Rats" International Journal of Molecular Sciences 22, no. 16: 8475. https://doi.org/10.3390/ijms22168475

APA Style

Jíchová, Š., Gawryś, O., Kompanowska-Jezierska, E., Sadowski, J., Melenovský, V., Hošková, L., Červenka, L., Kala, P., Veselka, J., & Čertíková Chábová, V. (2021). Kidney Response to Chemotherapy-Induced Heart Failure: mRNA Analysis in Normotensive and Ren-2 Transgenic Hypertensive Rats. International Journal of Molecular Sciences, 22(16), 8475. https://doi.org/10.3390/ijms22168475

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