Next Article in Journal
Novel High Affinity Sigma-1 Receptor Ligands from Minimal Ensemble Docking-Based Virtual Screening
Next Article in Special Issue
Sex Differences in Otolaryngology: Focus on the Emerging Role of Estrogens in Inflammatory and Pro-Resolving Responses
Previous Article in Journal
The Mechanism and Effect of Autophagy, Apoptosis, and Pyroptosis on the Progression of Silicosis
Previous Article in Special Issue
Hepatic LKB1 Reduces the Progression of Non-Alcoholic Fatty Liver Disease via Genomic Androgen Receptor Signaling
Review

Sex Differences in the Triad of Acquired Sensorineural Hearing Loss

by 1,2 and 3,*
1
Department of Otolaryngology-Head & Neck Surgery, Chang Gung Memorial Hospital, Linkou Branch, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
2
Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan
3
Department of Otolaryngology-Head & Neck Surgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Laszlo Prokai
Int. J. Mol. Sci. 2021, 22(15), 8111; https://doi.org/10.3390/ijms22158111
Received: 25 June 2021 / Revised: 17 July 2021 / Accepted: 26 July 2021 / Published: 28 July 2021
(This article belongs to the Special Issue Steroid Hormones and Sex Difference in Diseases)
The triad of noise-generated, drug-induced, and age-related hearing loss is the major cause of acquired sensorineural hearing loss (ASNHL) in modern society. Although these three forms of hearing loss display similar underlying mechanisms, detailed studies have revealed the presence of sex differences in the auditory system both in human and animal models of ASNHL. However, the sexual dimorphism of hearing varies among noise-induced hearing loss (NIHL), ototoxicity, and age-related hearing loss (ARHL). Importantly, estrogen may play an essential role in modulating the pathophysiological mechanisms in the cochlea and several reports have shown that the effects of hormone replacement therapy on hearing loss are complex. This review will summarize the clinical features of sex differences in ASNHL, compare the animal investigations of cochlear sexual dimorphism in response to the three insults, and address how estrogen affects the auditory organ at molecular levels. View Full-Text
Keywords: acquired sensorineural hearing loss; noise trauma; ototoxicity; presbycusis; estrogen; cochlea; sexual dimorphism acquired sensorineural hearing loss; noise trauma; ototoxicity; presbycusis; estrogen; cochlea; sexual dimorphism
Show Figures

Figure 1

MDPI and ACS Style

Lien, K.-H.; Yang, C.-H. Sex Differences in the Triad of Acquired Sensorineural Hearing Loss. Int. J. Mol. Sci. 2021, 22, 8111. https://doi.org/10.3390/ijms22158111

AMA Style

Lien K-H, Yang C-H. Sex Differences in the Triad of Acquired Sensorineural Hearing Loss. International Journal of Molecular Sciences. 2021; 22(15):8111. https://doi.org/10.3390/ijms22158111

Chicago/Turabian Style

Lien, Kuang-Hsu, and Chao-Hui Yang. 2021. "Sex Differences in the Triad of Acquired Sensorineural Hearing Loss" International Journal of Molecular Sciences 22, no. 15: 8111. https://doi.org/10.3390/ijms22158111

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop