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Article

Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass

1
Refractories, Ceramics and Building Materials Department, National Research Centre, 33El Bohouth St. (Former EL Tahrir St.), Dokki, Giza P.O. 12622, Egypt
2
Institute for Materials Chemistry and Engineering, Kyushu University, Fukuoka 812-8582, Japan
*
Author to whom correspondence should be addressed.
Academic Editors: Mike Barbeck, Ole Jung and Stevo Najman
Int. J. Mol. Sci. 2021, 22(15), 8038; https://doi.org/10.3390/ijms22158038
Received: 24 June 2021 / Revised: 13 July 2021 / Accepted: 16 July 2021 / Published: 27 July 2021
(This article belongs to the Special Issue Biomaterials for Bone Tissue Engineering 2.0)
Intermediate water (IW) in hydrated bioactive glasses remains uninvestigated. We obtained titanium (Ti)-containing bioactive glasses (BGTs) (Ti at 5%, 7.5% and 10% of the glass system) using the sol–gel technique. Their thermal, physicochemical, and morphological properties, before and after Ti-doping, were analysed using DTA, XRD, FTIR, TEM, and SEM accessorised with EDAX, and size distribution and zeta potential surface charges were determined using a NanoZetasizer. The IW in hydrated BGTs was investigated by cooling and heating runs of DSC measurements. Moreover, the mode of death in an osteosarcoma cell line (MG63) was evaluated at different times of exposure to BGT discs. Ti doping had no remarkable effect on the thermal, physicochemical, and morphological properties of BGTs. However, the morphology, size, and charges of BGT nano-powders were slightly changed after inclusion of Ti compared with those of BGT0; for example, the particle size increased with increasing Ti content (from 4–5 to 7–28 nm). The IW content was enhanced in the presence of Ti. The mode of cell death revealed the effect of IW content on the proliferation of cells exposed to BGTs. These findings should help improve the biocompatibility of inorganic biomaterials. View Full-Text
Keywords: intermediate water; bioactive glass; Ti-doping; biocompatibility intermediate water; bioactive glass; Ti-doping; biocompatibility
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MDPI and ACS Style

Mabrouk, M.; Beherei, H.H.; Tanaka, Y.; Tanaka, M. Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass. Int. J. Mol. Sci. 2021, 22, 8038. https://doi.org/10.3390/ijms22158038

AMA Style

Mabrouk M, Beherei HH, Tanaka Y, Tanaka M. Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass. International Journal of Molecular Sciences. 2021; 22(15):8038. https://doi.org/10.3390/ijms22158038

Chicago/Turabian Style

Mabrouk, Mostafa, Hanan H. Beherei, Yukiko Tanaka, and Masaru Tanaka. 2021. "Investigating the Intermediate Water Feature of Hydrated Titanium Containing Bioactive Glass" International Journal of Molecular Sciences 22, no. 15: 8038. https://doi.org/10.3390/ijms22158038

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