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Review

Tissue-Specific Decellularized Extracellular Matrix Bioinks for Musculoskeletal Tissue Regeneration and Modeling Using 3D Bioprinting Technology

by 1,†, 2,† and 1,3,4,*
1
Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang 37673, Korea
2
Institute of Engineering Medicine, Beijing Institute of Technology, Beijing 100081, China
3
POSTECH-Catholic Biomedical Engineering Institute, Pohang University of Science and Technology, Pohang 37673, Korea
4
Institute of Convergence Science, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Isabel Andia
Int. J. Mol. Sci. 2021, 22(15), 7837; https://doi.org/10.3390/ijms22157837
Received: 30 June 2021 / Revised: 20 July 2021 / Accepted: 20 July 2021 / Published: 22 July 2021
(This article belongs to the Special Issue Medical Applications for 3D Bioprinting)
The musculoskeletal system is a vital body system that protects internal organs, supports locomotion, and maintains homeostatic function. Unfortunately, musculoskeletal disorders are the leading cause of disability worldwide. Although implant surgeries using autografts, allografts, and xenografts have been conducted, several adverse effects, including donor site morbidity and immunoreaction, exist. To overcome these limitations, various biomedical engineering approaches have been proposed based on an understanding of the complexity of human musculoskeletal tissue. In this review, the leading edge of musculoskeletal tissue engineering using 3D bioprinting technology and musculoskeletal tissue-derived decellularized extracellular matrix bioink is described. In particular, studies on in vivo regeneration and in vitro modeling of musculoskeletal tissue have been focused on. Lastly, the current breakthroughs, limitations, and future perspectives are described. View Full-Text
Keywords: musculoskeletal tissue; tissue engineering; 3D bioprinting; decellularized extracellular matrix bioink musculoskeletal tissue; tissue engineering; 3D bioprinting; decellularized extracellular matrix bioink
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MDPI and ACS Style

Park, W.; Gao, G.; Cho, D.-W. Tissue-Specific Decellularized Extracellular Matrix Bioinks for Musculoskeletal Tissue Regeneration and Modeling Using 3D Bioprinting Technology. Int. J. Mol. Sci. 2021, 22, 7837. https://doi.org/10.3390/ijms22157837

AMA Style

Park W, Gao G, Cho D-W. Tissue-Specific Decellularized Extracellular Matrix Bioinks for Musculoskeletal Tissue Regeneration and Modeling Using 3D Bioprinting Technology. International Journal of Molecular Sciences. 2021; 22(15):7837. https://doi.org/10.3390/ijms22157837

Chicago/Turabian Style

Park, Wonbin, Ge Gao, and Dong-Woo Cho. 2021. "Tissue-Specific Decellularized Extracellular Matrix Bioinks for Musculoskeletal Tissue Regeneration and Modeling Using 3D Bioprinting Technology" International Journal of Molecular Sciences 22, no. 15: 7837. https://doi.org/10.3390/ijms22157837

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