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Phelan McDermid Syndrome: Multiple Sclerosis as a Rare but Treatable Cause for Regression—A Case Report

MicroRNAs, Multiple Sclerosis, and Depression

Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan
Academic Editor: Damiana Pieragostino
Int. J. Mol. Sci. 2021, 22(15), 7802;
Received: 7 June 2021 / Revised: 12 July 2021 / Accepted: 16 July 2021 / Published: 21 July 2021
(This article belongs to the Special Issue Molecular Research in Multiple Sclerosis)
Multiple sclerosis (MS) is a chronic disease of the central nervous system that affects the brain and spinal cord. There are several disease courses in MS including relapsing–remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS). Up to 50% of MS patients experience depressive disorders. Major depression (MD) is a serious comorbidity of MS. Many dysfunctions including neuroinflammation, peripheral inflammation, gut dysbiosis, chronic oxidative and nitrosative stress, and neuroendocrine and mitochondrial abnormalities may contribute to the comorbidity between MS and MD. In addition to these actions, medical treatment and microRNA (miRNA) regulation may also be involved in the mechanisms of the comorbidity between MS and MD. In the study, I review many common miRNA biomarkers for both diseases. These common miRNA biomarkers may help further explore the association between MS and MD. View Full-Text
Keywords: biomarker; depression; microRNA; multiple sclerosis; treatment biomarker; depression; microRNA; multiple sclerosis; treatment
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MDPI and ACS Style

Wang, H. MicroRNAs, Multiple Sclerosis, and Depression. Int. J. Mol. Sci. 2021, 22, 7802.

AMA Style

Wang H. MicroRNAs, Multiple Sclerosis, and Depression. International Journal of Molecular Sciences. 2021; 22(15):7802.

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Wang, Hsiuying. 2021. "MicroRNAs, Multiple Sclerosis, and Depression" International Journal of Molecular Sciences 22, no. 15: 7802.

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