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Article

Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.)

1
Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA
2
Department of Food Science, University of Tennessee, Knoxville, TN 37996, USA
3
Plants for Human Health Institute, North Carolina State University, Kannapolis, NC 28081, USA
4
Department of Biology, Catawba College, Salisbury, NC 28144, USA
5
Department of Food, Bioprocessing & Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Raffaele Capasso
Int. J. Mol. Sci. 2021, 22(14), 7382; https://doi.org/10.3390/ijms22147382
Received: 18 May 2021 / Revised: 22 June 2021 / Accepted: 26 June 2021 / Published: 9 July 2021
(This article belongs to the Special Issue Natural Product Pharmacology)
Culinary sage (Salvia officinalis L.) is a common spice plant in the mint family (Lamiaceae) well known for its distinctive culinary and traditional medicinal uses. Sage tea has been used traditionally as a brain-enhancing tonic and extracts from sage have been reported to have both cognitive and memory enhancing effects. Brain-derived neurotrophic factor (BDNF) is an endogenous signaling molecule involved in cognition and memory function. In this study, activity-guided fractionation employing preparative reverse-phase high performance liquid chromatography (RP-HPLC) of culinary sage extracts led to the discovery of benzyl 6-O-β-D-apiofuranosyl-β-D-glucoside (B6AG) as a natural product that upregulates transcription of neurotrophic factors in C6 glioma cells. Purified B6AG showed a moderate dose response, with upregulation of BDNF and with EC50 at 6.46 μM. To better understand the natural variation in culinary sage, B6AG was quantitated in the leaves of several commercial varieties by liquid chromatography-mass spectrometry (LC-MS). The level of B6AG in dried culinary sage was found to range from 334 ± 14 to 698 ± 65 μg/g. This study provided a foundation for future investigations, including quantitative inquiries on the distribution of B6AG within the different plant organs, explorations in optimizing post-harvest practices, and aid in the development of sage varieties with elevated levels of B6AG. View Full-Text
Keywords: culinary sage; cognition and memory function; brain-derived neurotrophic factor (BDNF); sage extract; benzyl 6-O-β-D-apiofuranosyl-β-D-glucoside (B6AG) culinary sage; cognition and memory function; brain-derived neurotrophic factor (BDNF); sage extract; benzyl 6-O-β-D-apiofuranosyl-β-D-glucoside (B6AG)
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MDPI and ACS Style

Chiang, N.; Ray, S.; Lomax, J.; Goertzen, S.; Komarnytsky, S.; Ho, C.-T.; Munafo, J.P., Jr. Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.). Int. J. Mol. Sci. 2021, 22, 7382. https://doi.org/10.3390/ijms22147382

AMA Style

Chiang N, Ray S, Lomax J, Goertzen S, Komarnytsky S, Ho C-T, Munafo JP Jr. Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.). International Journal of Molecular Sciences. 2021; 22(14):7382. https://doi.org/10.3390/ijms22147382

Chicago/Turabian Style

Chiang, Nancy, Shahla Ray, Jade Lomax, Sydney Goertzen, Slavko Komarnytsky, Chi-Tang Ho, and John P. Munafo Jr. 2021. "Modulation of Brain-Derived Neurotrophic Factor (BDNF) Signaling Pathway by Culinary Sage (Salvia officinalis L.)" International Journal of Molecular Sciences 22, no. 14: 7382. https://doi.org/10.3390/ijms22147382

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