Next Article in Journal
Osteoblast Differentiation and Signaling: Established Concepts and Emerging Topics
Next Article in Special Issue
From Genetics to Histomolecular Characterization: An Insight into Colorectal Carcinogenesis in Lynch Syndrome
Previous Article in Journal
Soybean (Glycine max) Is Able to Absorb, Metabolize and Accumulate Fenbendazole in All Organs Including Beans
Previous Article in Special Issue
Molecular Alterations in Gastric Intestinal Metaplasia
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 13
10.3390/ijms22136652
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer

by
Serena Battista
1,*,†,
Maria Raffaella Ambrosio
2,†,
Francesco Limarzi
3,†,
Graziana Gallo
4,† and
Luca Saragoni
3,†
1
Pathology Department, “S. Maria della Misericordia Hospital”, Friuli-Venezia Giulia, 33100 Udine, Italy
2
Pathology Department, “Az. USL, Tuscany North-West”, Tuscany, 56121 Pisa, Italy
3
Pathology Department, “G.B. Morgagni-L. Pierantoni Hospital”, Emilia-Romagna, 47121 Forlì, Italy
4
Pathology Department, “M. Bufalini Hospital”, Emilia Romagna, 47521 Cesena, Italy
*
Author to whom correspondence should be addressed.
†
On behalf of the Italian Research Group for Gastric Cancer (GIRCG).
Int. J. Mol. Sci. 2021, 22(13), 6652; https://doi.org/10.3390/ijms22136652
Submission received: 13 May 2021 / Revised: 11 June 2021 / Accepted: 15 June 2021 / Published: 22 June 2021
(This article belongs to the Special Issue Molecular Alterations in GastroIntestinal Pre-invasive Lesions)
Browse Figures
Review Reports Versions Notes

Abstract

Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and early gastric cancer. In particular, considering preinvasive neoplasia and early gastric cancer, some studies have demonstrated a correlation between molecular alterations and prognosis, for example, mucins phenotype in gastric dysplasia, and GATA6, TP53 mutation/LOH and MUC6 in early gastric cancer. Moreover, this review considers novelties from the literature regarding the (immuno)histochemical characterization of diffuse-type/signet ring cell gastric cancer, with particular attention to clinical outcomes of patients. The aim of this review is the evaluation of the state of the art regarding suitable biomarkers used in the pre-surgical phase, which can distinguish patients with different prognoses and help decide the best therapeutic strategy.
Keywords: gastric preinvasive neoplasia; early gastric cancer; signet ring cell gastric carcinoma; mucins expression; molecular markers gastric preinvasive neoplasia; early gastric cancer; signet ring cell gastric carcinoma; mucins expression; molecular markers

Share and Cite

MDPI and ACS Style

Battista, S.; Ambrosio, M.R.; Limarzi, F.; Gallo, G.; Saragoni, L. Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer. Int. J. Mol. Sci. 2021, 22, 6652. https://doi.org/10.3390/ijms22136652

AMA Style

Battista S, Ambrosio MR, Limarzi F, Gallo G, Saragoni L. Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer. International Journal of Molecular Sciences. 2021; 22(13):6652. https://doi.org/10.3390/ijms22136652

Chicago/Turabian Style

Battista, Serena, Maria Raffaella Ambrosio, Francesco Limarzi, Graziana Gallo, and Luca Saragoni. 2021. "Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer" International Journal of Molecular Sciences 22, no. 13: 6652. https://doi.org/10.3390/ijms22136652

APA Style

Battista, S., Ambrosio, M. R., Limarzi, F., Gallo, G., & Saragoni, L. (2021). Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer. International Journal of Molecular Sciences, 22(13), 6652. https://doi.org/10.3390/ijms22136652

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop