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Lymphatic Connexins and Pannexins in Health and Disease
Review

Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence

1
Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Bydgoska Street 7, 10-243 Olsztyn, Poland
2
Department of Basic and Preclinical Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University, Gagarina Street 7, 87-100 Torun, Poland
3
Department of Reproduction and Gynecological Endocrinology, Medical University of Bialystok, Jana Kilińskiego Street 1, 15-089 Białystok, Poland
4
Center of Gynecology, Endocrinology and Reproductive Medicine—Artemida, Jagiellońska Street 78, 10-357 Olsztyn, Poland
5
Department of Human Physiology and Pathophysiology, School of Medicine, Collegium Medicum, University of Warmia and Mazury, Warszawska Street 30, 10-357 Olsztyn, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Mathieu Vinken
Int. J. Mol. Sci. 2021, 22(11), 5918; https://doi.org/10.3390/ijms22115918
Received: 13 April 2021 / Revised: 23 May 2021 / Accepted: 28 May 2021 / Published: 31 May 2021
(This article belongs to the Special Issue Connexin and Pannexin Signaling in Health and Disease 2.0)
The oocyte is the major determinant of embryo developmental competence in all mammalian species. Although fundamental advances have been generated in the field of reproductive medicine and assisted reproductive technologies in the past three decades, researchers and clinicians are still trying to elucidate molecular factors and pathways, which could be pivotal for the oocyte’s developmental competence. The cell-to-cell and cell-to-matrix communications are crucial not only for oocytes but also for multicellular organisms in general. This latter mentioned communication is among others possibly due to the Connexin and Pannexin families of large-pore forming channels. Pannexins belong to a protein group of ATP-release channels, therefore of high importance for the oocyte due to its requirements of high energy supply. An increasing body of studies on Pannexins provided evidence that these channels not only play a role during physiological processes of an oocyte but also during pathological circumstances which could lead to the development of diseases or infertility. Connexins are proteins that form membrane channels and gap-junctions, and more precisely, these proteins enable the exchange of some ions and molecules, and therefore they do play a fundamental role in the communication between the oocyte and accompanying cells. Herein, the role of Pannexins and Connexins for the processes of oogenesis, folliculogenesis, oocyte maturation and fertilization will be discussed and, at the end of this review, Pannexin and Connexin related pathologies and their impact on the developmental competence of oocytes will be provided. View Full-Text
Keywords: pannexin; connexin; oocyte; developmental competence; oogenesis; maturation; fertilization pannexin; connexin; oocyte; developmental competence; oogenesis; maturation; fertilization
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MDPI and ACS Style

Kordowitzki, P.; Sokołowska, G.; Wasielak-Politowska, M.; Skowronska, A.; Skowronski, M.T. Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence. Int. J. Mol. Sci. 2021, 22, 5918. https://doi.org/10.3390/ijms22115918

AMA Style

Kordowitzki P, Sokołowska G, Wasielak-Politowska M, Skowronska A, Skowronski MT. Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence. International Journal of Molecular Sciences. 2021; 22(11):5918. https://doi.org/10.3390/ijms22115918

Chicago/Turabian Style

Kordowitzki, Paweł, Gabriela Sokołowska, Marta Wasielak-Politowska, Agnieszka Skowronska, and Mariusz T. Skowronski 2021. "Pannexins and Connexins: Their Relevance for Oocyte Developmental Competence" International Journal of Molecular Sciences 22, no. 11: 5918. https://doi.org/10.3390/ijms22115918

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