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Review

Gangliosides as Signaling Regulators in Cancer

1
Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
2
Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
*
Authors to whom correspondence should be addressed.
Academic Editor: Paola Giussani
Int. J. Mol. Sci. 2021, 22(10), 5076; https://doi.org/10.3390/ijms22105076
Received: 18 April 2021 / Revised: 7 May 2021 / Accepted: 7 May 2021 / Published: 11 May 2021
(This article belongs to the Special Issue Sphingolipid Metabolism and Signaling in Diseases)
At the plasma membrane, gangliosides, a group of glycosphingolipids, are expressed along with glycosphingolipids, phospholipids, and cholesterol in so-called lipid rafts that interact with signaling receptors and related molecules. Most cancers present abnormalities in the intracellular signal transduction system involved in tumor growth, invasion, and metastasis. To date, the roles of gangliosides as regulators of signal transduction have been reported in several cancer types. Gangliosides can be expressed by the exogenous ganglioside addition, with their endogenous expression regulated at the enzymatic level by targeting specific glycosyltransferases. Accordingly, the relationship between changes in the composition of cell surface gangliosides and signal transduction has been investigated by controlling ganglioside expression. In cancer cells, several types of signaling molecules are positively or negatively regulated by ganglioside expression levels, promoting malignant properties. Moreover, antibodies against gangliosides have been shown to possess cytotoxic effects on ganglioside-expressing cancer cells. In the present review, we highlight the involvement of gangliosides in the regulation of cancer cell signaling, and we explore possible therapies targeting ganglioside-expressing cancer. View Full-Text
Keywords: cancer; ganglioside; signaling; receptor cancer; ganglioside; signaling; receptor
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MDPI and ACS Style

Sasaki, N.; Toyoda, M.; Ishiwata, T. Gangliosides as Signaling Regulators in Cancer. Int. J. Mol. Sci. 2021, 22, 5076. https://doi.org/10.3390/ijms22105076

AMA Style

Sasaki N, Toyoda M, Ishiwata T. Gangliosides as Signaling Regulators in Cancer. International Journal of Molecular Sciences. 2021; 22(10):5076. https://doi.org/10.3390/ijms22105076

Chicago/Turabian Style

Sasaki, Norihiko; Toyoda, Masashi; Ishiwata, Toshiyuki. 2021. "Gangliosides as Signaling Regulators in Cancer" Int. J. Mol. Sci. 22, no. 10: 5076. https://doi.org/10.3390/ijms22105076

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