Next Article in Journal
Chronic Ouabain Prevents Na,K-ATPase Dysfunction and Targets AMPK and IL-6 in Disused Rat Soleus Muscle
Next Article in Special Issue
Gangliosides as Signaling Regulators in Cancer
Previous Article in Journal
Modeling Neoplastic Growth in Renal Cell Carcinoma and Polycystic Kidney Disease
Previous Article in Special Issue
Differential Expression of Sphingolipid Metabolizing Enzymes in Spontaneously Hypertensive Rats: A Possible Substrate for Susceptibility to Brain and Kidney Damage
Article

The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo

1
Servicio de Bioquímica-Investigación, Hospital Universitario Ramón y Cajal, IRyCIS, 28034 Madrid, Spain
2
Servicio de Bioquímica-Clínica, Hospital Universitario Ramón y Cajal, IRyCIS, 28034 Madrid, Spain
3
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
4
Servicio de Geriatría, Hospital Universitario Ramón y Cajal, IRyCIS, 28034 Madrid, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Paola Giussani
Int. J. Mol. Sci. 2021, 22(8), 3919; https://doi.org/10.3390/ijms22083919
Received: 17 March 2021 / Revised: 6 April 2021 / Accepted: 8 April 2021 / Published: 10 April 2021
(This article belongs to the Special Issue Sphingolipid Metabolism and Signaling in Diseases)
Atypical or second-generation antipsychotics are used in the treatment of psychosis and behavioral problems in older persons with dementia. However, these pharmaceutical drugs are associated with an increased risk of stroke in such patients. In this study, we evaluated the effects of risperidone treatment on phospholipid and sphingolipid composition and lipid raft function in peripheral blood mononuclear cells (PBMCs) of older patients (mean age >88 years). The results showed that the levels of dihydroceramides, very-long-chain ceramides, and lysophosphatidylcholines decreased in PBMCs of the risperidone-treated group compared with untreated controls. These findings were confirmed by in vitro assays using human THP-1 monocytes. The reduction in the levels of very-long-chain ceramides and dihydroceramides could be due to the decrease in the expression of fatty acid elongase 3, as observed in THP-1 monocytes. Moreover, risperidone disrupted lipid raft domains in the plasma membrane of PBMCs. These results indicated that risperidone alters phospholipid and sphingolipid composition and lipid raft domains in PBMCs of older patients, potentially affecting multiple signaling pathways associated with these membrane domains. View Full-Text
Keywords: antipsychotic; risperidone; older person; lipid metabolism; sphingolipid; lysophospholipid antipsychotic; risperidone; older person; lipid metabolism; sphingolipid; lysophospholipid
Show Figures

Figure 1

MDPI and ACS Style

Canfrán-Duque, A.; Pastor, Ó.; García-Seisdedos, D.; Molina, Y.L.; Babiy, B.; Lerma, M.; Sánchez-Castellano, C.; Martínez-Botas, J.; Gómez-Coronado, D.; Lasunción, M.A.; Cruz-Jentoft, A.J.; Busto, R. The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo. Int. J. Mol. Sci. 2021, 22, 3919. https://doi.org/10.3390/ijms22083919

AMA Style

Canfrán-Duque A, Pastor Ó, García-Seisdedos D, Molina YL, Babiy B, Lerma M, Sánchez-Castellano C, Martínez-Botas J, Gómez-Coronado D, Lasunción MA, Cruz-Jentoft AJ, Busto R. The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo. International Journal of Molecular Sciences. 2021; 22(8):3919. https://doi.org/10.3390/ijms22083919

Chicago/Turabian Style

Canfrán-Duque, Alberto, Óscar Pastor, David García-Seisdedos, Yessenia L. Molina, Bohdan Babiy, Milagros Lerma, Carmen Sánchez-Castellano, Javier Martínez-Botas, Diego Gómez-Coronado, Miguel A. Lasunción, Alfonso J. Cruz-Jentoft, and Rebeca Busto. 2021. "The Antipsychotic Risperidone Alters Dihydroceramide and Ceramide Composition and Plasma Membrane Function in Leukocytes In Vitro and In Vivo" International Journal of Molecular Sciences 22, no. 8: 3919. https://doi.org/10.3390/ijms22083919

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop