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Review

The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone

1
Mildred Scheel Early Career Center, Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine III, Technische Universität Dresden, 01159 Dresden, Germany
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German Cancer Consortium (DKTK), Partner Site Dresden and German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
3
Center for Healthy Aging, Technische Universität Dresden, 01159 Dresden, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Ingunn Holen
Int. J. Mol. Sci. 2021, 22(10), 5078; https://doi.org/10.3390/ijms22105078
Received: 18 March 2021 / Revised: 7 May 2021 / Accepted: 10 May 2021 / Published: 11 May 2021
Tumor metastasis to bone is a common event in multiple forms of malignancy. Inflammation holds essential functions in homeostasis as a defense mechanism against infections and is a strategy to repair injured tissue and to adapt to stress conditions. However, exaggerated and/or persistent (chronic) inflammation may eventually become maladaptive and evoke diseases such as autoimmunity, diabetes, inflammatory tissue damage, fibrosis, and cancer. In fact, inflammation is now considered a hallmark of malignancy with prognostic relevance. Emerging studies have revealed a central involvement of inflammation in several steps of the metastatic cascade of bone-homing tumor cells through supporting their survival, migration, invasion, and growth. The mechanisms by which inflammation favors these steps involve activation of epithelial-to-mesenchymal transition (EMT), chemokine-mediated homing of tumor cells, local activation of osteoclastogenesis, and a positive feedback amplification of the protumorigenic inflammation loop between tumor and resident cells. In this review, we summarize established and evolving concepts of inflammation-driven tumorigenesis, with a special focus on bone metastasis. View Full-Text
Keywords: inflammation; metastasis; cancer; bone colonization; tumor microenvironment inflammation; metastasis; cancer; bone colonization; tumor microenvironment
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MDPI and ACS Style

Göbel, A.; Dell’Endice, S.; Jaschke, N.; Pählig, S.; Shahid, A.; Hofbauer, L.C.; Rachner, T.D. The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone. Int. J. Mol. Sci. 2021, 22, 5078. https://doi.org/10.3390/ijms22105078

AMA Style

Göbel A, Dell’Endice S, Jaschke N, Pählig S, Shahid A, Hofbauer LC, Rachner TD. The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone. International Journal of Molecular Sciences. 2021; 22(10):5078. https://doi.org/10.3390/ijms22105078

Chicago/Turabian Style

Göbel, Andy, Stefania Dell’Endice, Nikolai Jaschke, Sophie Pählig, Amna Shahid, Lorenz C. Hofbauer, and Tilman D. Rachner 2021. "The Role of Inflammation in Breast and Prostate Cancer Metastasis to Bone" International Journal of Molecular Sciences 22, no. 10: 5078. https://doi.org/10.3390/ijms22105078

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