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Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning

Cardiometabolic Research Group and MTA-SE System Pharmacology Research Group Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary
Pharmahungary Group, H-6720 Szeged, Hungary
Department of Physiology, Justus-Liebig-University, 35390 Giessen, Germany
Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany
Department of Pharmacology and Pharmacotherapy, University of Szeged, H-6721 Szeged, Hungary
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3359;
Received: 8 April 2020 / Revised: 30 April 2020 / Accepted: 4 May 2020 / Published: 9 May 2020
(This article belongs to the Special Issue Myocardial Infarction and Myocardial Protection)
Swiprosin-1 (EFhD2) is a molecule that triggers structural adaptation of isolated adult rat cardiomyocytes to cell culture conditions by initiating a process known as cell spreading. This process mimics central aspects of cardiac remodeling, as it occurs subsequent to myocardial infarction. However, expression of swiprosin-1 in cardiac tissue and its regulation in vivo has not yet been addressed. The expression of swiprosin-1 was analyzed in mice, rat, and pig hearts undergoing myocardial infarction or ischemia/reperfusion with or without cardiac protection by ischemic pre- and postconditioning. In mouse hearts, swiprosin-1 protein expression was increased after 4 and 7 days in myocardial infarct areas specifically in cardiomyocytes as verified by immunoblotting and histology. In rat hearts, swiprosin-1 mRNA expression was induced within 7 days after ischemia/reperfusion but this induction was abrogated by conditioning. As in cultured cardiomyocytes, the expression of swiprosin-1 was associated with a coinduction of arrestin-2, suggesting a common mechanism of regulation. Rno-miR-32-3p and rno-miR-34c-3p were associated with the regulation pattern of both molecules. Moreover, induction of swiprosin-1 and ssc-miR-34c was also confirmed in the infarct zone of pigs. In summary, our data show that up-regulation of swiprosin-1 appears in the postischemic heart during cardiac remodeling and repair in different species. View Full-Text
Keywords: cardiac regeneration; cardiac protection; miR-34 cardiac regeneration; cardiac protection; miR-34
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MDPI and ACS Style

Giricz, Z.; Makkos, A.; Schreckenberg, R.; Pöling, J.; Lörchner, H.; Kiss, K.; Bencsik, P.; Braun, T.; Schulz, R.; Ferdinandy, P.; Schlüter, K.-D. Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning. Int. J. Mol. Sci. 2020, 21, 3359.

AMA Style

Giricz Z, Makkos A, Schreckenberg R, Pöling J, Lörchner H, Kiss K, Bencsik P, Braun T, Schulz R, Ferdinandy P, Schlüter K-D. Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning. International Journal of Molecular Sciences. 2020; 21(9):3359.

Chicago/Turabian Style

Giricz, Zoltán, András Makkos, Rolf Schreckenberg, Jochen Pöling, Holger Lörchner, Krisztina Kiss, Péter Bencsik, Thomas Braun, Rainer Schulz, Péter Ferdinandy, and Klaus-Dieter Schlüter. 2020. "Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning" International Journal of Molecular Sciences 21, no. 9: 3359.

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