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Article

Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning

1
Cardiometabolic Research Group and MTA-SE System Pharmacology Research Group Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1085 Budapest, Hungary
2
Pharmahungary Group, H-6720 Szeged, Hungary
3
Department of Physiology, Justus-Liebig-University, 35390 Giessen, Germany
4
Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231 Bad Nauheim, Germany
5
Department of Pharmacology and Pharmacotherapy, University of Szeged, H-6721 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3359; https://doi.org/10.3390/ijms21093359
Received: 8 April 2020 / Revised: 30 April 2020 / Accepted: 4 May 2020 / Published: 9 May 2020
(This article belongs to the Special Issue Myocardial Infarction and Myocardial Protection)
Swiprosin-1 (EFhD2) is a molecule that triggers structural adaptation of isolated adult rat cardiomyocytes to cell culture conditions by initiating a process known as cell spreading. This process mimics central aspects of cardiac remodeling, as it occurs subsequent to myocardial infarction. However, expression of swiprosin-1 in cardiac tissue and its regulation in vivo has not yet been addressed. The expression of swiprosin-1 was analyzed in mice, rat, and pig hearts undergoing myocardial infarction or ischemia/reperfusion with or without cardiac protection by ischemic pre- and postconditioning. In mouse hearts, swiprosin-1 protein expression was increased after 4 and 7 days in myocardial infarct areas specifically in cardiomyocytes as verified by immunoblotting and histology. In rat hearts, swiprosin-1 mRNA expression was induced within 7 days after ischemia/reperfusion but this induction was abrogated by conditioning. As in cultured cardiomyocytes, the expression of swiprosin-1 was associated with a coinduction of arrestin-2, suggesting a common mechanism of regulation. Rno-miR-32-3p and rno-miR-34c-3p were associated with the regulation pattern of both molecules. Moreover, induction of swiprosin-1 and ssc-miR-34c was also confirmed in the infarct zone of pigs. In summary, our data show that up-regulation of swiprosin-1 appears in the postischemic heart during cardiac remodeling and repair in different species. View Full-Text
Keywords: cardiac regeneration; cardiac protection; miR-34 cardiac regeneration; cardiac protection; miR-34
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MDPI and ACS Style

Giricz, Z.; Makkos, A.; Schreckenberg, R.; Pöling, J.; Lörchner, H.; Kiss, K.; Bencsik, P.; Braun, T.; Schulz, R.; Ferdinandy, P.; Schlüter, K.-D. Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning. Int. J. Mol. Sci. 2020, 21, 3359. https://doi.org/10.3390/ijms21093359

AMA Style

Giricz Z, Makkos A, Schreckenberg R, Pöling J, Lörchner H, Kiss K, Bencsik P, Braun T, Schulz R, Ferdinandy P, Schlüter K-D. Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning. International Journal of Molecular Sciences. 2020; 21(9):3359. https://doi.org/10.3390/ijms21093359

Chicago/Turabian Style

Giricz, Zoltán, András Makkos, Rolf Schreckenberg, Jochen Pöling, Holger Lörchner, Krisztina Kiss, Péter Bencsik, Thomas Braun, Rainer Schulz, Péter Ferdinandy, and Klaus-Dieter Schlüter. 2020. "Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning" International Journal of Molecular Sciences 21, no. 9: 3359. https://doi.org/10.3390/ijms21093359

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