Airway Microbiota as a Modulator of Lung Cancer
Round 1
Reviewer 1 Report
The manuscript is a review with no unpublished original data but is a fair presentation of the literature from the basic information about the bacterial microbiome in respiratory system to the data about lung microbiome in COPD, asthma and pulmonary fibrosis to end with cancer in general and lung cancer in detail. The authors also try to explain the associations between lung cancer and bacterial microbiome and its role in cancer pathogenesis as well as the impact of microbiome on immunotherapy outcome in lung cancer patients.
I find the manuscript well organized, with good literature selection, it is a comprehensive review in the presented field and ready to be published in my opinion.
Reviewer 2 Report
The Author aimed to discuss the basic role of the airway microbiome in carcinogenesis and the underlying molecular mechanisms, as microorganisms possibly trigger tumor initiation and progression, possibly by releasing bacterial toxins and other pro-inflammatory factors.
The review is well-structured and presents updated information about next-generation diagnostic approaches, as well as a wide description of evidences in different lung diseases, both neoplastic and non-neoplastic.
Some grammar/spelling should be corrected, but the review can be accepted for publication.
