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Estrogen Receptors and Endometriosis

1
IUCT Oncopole, 31100 Toulouse, France
2
INSERM-UPS UMR U1048, Institut des Maladies Métaboliques et Cardiovasculaires, Université de Toulouse, BP 84225, CEDEX 04, 31 432 Toulouse, France
3
Department of Visceral Surgery, CHU Rangueil, 31400 Toulouse, France
4
Urosphere, Rue des Satellites, 31400 Toulouse, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(8), 2815; https://doi.org/10.3390/ijms21082815
Received: 28 February 2020 / Revised: 10 April 2020 / Accepted: 15 April 2020 / Published: 17 April 2020
(This article belongs to the Special Issue Molecular Research of Endometrial Pathophysiology 2.0)
Endometriosis is a frequent and chronic inflammatory disease with impacts on reproduction, health and quality of life. This disorder is highly estrogen-dependent and the purpose of hormonal treatments is to decrease the endogenous ovarian production of estrogens. High estrogen production is a consistently observed endocrine feature of endometriosis. mRNA and protein levels of estrogen receptors (ER) are different between a normal healthy endometrium and ectopic/eutopic endometrial lesions: endometriotic stromal cells express extraordinarily higher ERβ and significantly lower ERα levels compared with endometrial stromal cells. Aberrant epigenetic regulation such as DNA methylation in endometriotic cells is associated with the pathogenesis and development of endometriosis. Although there is a large body of data regarding ERs in endometriosis, our understanding of the roles of ERα and ERβ in the pathogenesis of endometriosis remains incomplete. The goal of this review is to provide an overview of the links between endometriosis, ERs and the recent advances of treatment strategies based on ERs modulation. We will also attempt to summarize the current understanding of the molecular and cellular mechanisms of action of ERs and how this could pave the way to new therapeutic strategies. View Full-Text
Keywords: endometriosis; estrogen receptors; modulation; treatment strategy endometriosis; estrogen receptors; modulation; treatment strategy
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MDPI and ACS Style

Chantalat, E.; Valera, M.-C.; Vaysse, C.; Noirrit, E.; Rusidze, M.; Weyl, A.; Vergriete, K.; Buscail, E.; Lluel, P.; Fontaine, C.; Arnal, J.-F.; Lenfant, F. Estrogen Receptors and Endometriosis. Int. J. Mol. Sci. 2020, 21, 2815. https://doi.org/10.3390/ijms21082815

AMA Style

Chantalat E, Valera M-C, Vaysse C, Noirrit E, Rusidze M, Weyl A, Vergriete K, Buscail E, Lluel P, Fontaine C, Arnal J-F, Lenfant F. Estrogen Receptors and Endometriosis. International Journal of Molecular Sciences. 2020; 21(8):2815. https://doi.org/10.3390/ijms21082815

Chicago/Turabian Style

Chantalat, Elodie; Valera, Marie-Cécile; Vaysse, Charlotte; Noirrit, Emmanuelle; Rusidze, Mariam; Weyl, Ariane; Vergriete, Kelig; Buscail, Etienne; Lluel, Philippe; Fontaine, Coralie; Arnal, Jean-François; Lenfant, Françoise. 2020. "Estrogen Receptors and Endometriosis" Int. J. Mol. Sci. 21, no. 8: 2815. https://doi.org/10.3390/ijms21082815

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