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Open AccessArticle

Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model

1
Department of Pharmacy, Kumamoto University Hospital, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan
2
Department of Clinical Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan
3
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5–1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
4
Department of Clinical Chemistry and Informatics, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5–1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
5
Department of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Sojo University, 4-22-1 Ikeda, Nishi-ku, Kumamoto 860-0082, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(7), 2491; https://doi.org/10.3390/ijms21072491
Received: 18 February 2020 / Revised: 27 March 2020 / Accepted: 31 March 2020 / Published: 3 April 2020
(This article belongs to the Section Molecular Pharmacology)
Patients on dialysis are frequently administered high doses of potassium binders such as calcium polystyrene sulfonate (CPS) and sodium polystyrene sulfonate (SPS), which exacerbate constipation. Here, we compare the degree of constipation induced by CPS and SPS using a loperamide-induced constipation model to identify the safer potassium binder. Constipation model was created by twice-daily intraperitoneal administration (ip) of loperamide hydrochloride (Lop; 1 mg/kg body weight) in rats for 3 days. Rats were assigned to a control group, Lop group, Lop + CPS group or Lop + SPS group, and a crossover comparative study was performed. Defecation status (number of feces, feces wet weight, fecal water content and gastrointestinal transit time (GTT)) was evaluated. In the Lop + CPS group, GTT was significantly longer, and fecal water content was reduced. In the Lop + SPS group—although the fecal water content and GTT were unaffected—the number of fecal pellets and the fecal wet weight improved. Thus, SPS was less likely to cause constipation exacerbation than CPS. Considering the high frequency of constipation in dialysis patients with hyperkalemia, preferentially administering SPS over CPS may prevent constipation exacerbation. View Full-Text
Keywords: hemodialysis; constipation; rat; calcium polystyrene sulfonate; sodium polystyrene sulfonate hemodialysis; constipation; rat; calcium polystyrene sulfonate; sodium polystyrene sulfonate
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Narita, Y.; Fukumoto, K.; Fukunaga, M.; Kondo, Y.; Ishitsuka, Y.; Jono, H.; Irie, T.; Saito, H.; Kadowaki, D.; Hirata, S. Comparative Study of Constipation Exacerbation by Potassium Binders Using a Loperamide-Induced Constipation Model. Int. J. Mol. Sci. 2020, 21, 2491.

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