Next Article in Journal
Biophysical Techniques for Target Validation and Drug Discovery in Transcription-Targeted Therapy
Next Article in Special Issue
Array-Based Screening of Silver Nanoparticle Mineralization Peptides
Previous Article in Journal
Epigenetic Regulation of Auxin-Induced Somatic Embryogenesis in Plants
Previous Article in Special Issue
Photochemical Printing of Plasmonically Active Silver Nanostructures
Open AccessArticle

Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications

School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, PO1 2DT, Portsmouth, UK
Department of Architecture, Design and Urban Planning—GeoMaterials Lab, University of Sassari, Via Piandanna 4, 07100 Sassari, Italy
Zeiss Global Centre, School of Engineering, University of Portsmouth, Anglesea Building, Anglesea Road, PO1 3DJ Portsmouth, UK
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2303;
Received: 11 March 2020 / Revised: 25 March 2020 / Accepted: 25 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Silver Nano/Microparticles: Modification and Applications 2.0)
In this work, we prepared silver nanowires (AgNWs) via the polyol method in the presence or absence of single wall carbon nanotubes (CNTs) and tested their physicochemical, antibacterial and cytotoxic properties. Results showed that the introduction of CNTs lead to the formation of AgNWs at lower temperature, but the final product characteristics of AgNWs and AgNWs-CNT were not significantly different. AgNWs exhibited antibacterial properties against all the studied bacterial species via the formation of oxygen reactive species (ROS) and membrane damage. Furthermore, AgNWs exhibited a dose-dependent and time-dependent toxicity at concentrations ≥ 10 µg/mL. Fibroblasts appeared to be more resistant than human colorectal adenocarcinoma (Caco-2) and osteoblasts to the toxicity of AgNWs. The cytotoxicity of AgNWs was found to be related to the formation of ROS, but not to membrane damage. Overall, these results suggest that AgNWs are potential antibacterial agents against E. coli, S. aureus, MRSA and S. saprophyticus, but their dosage needs to be adjusted according to the route of administration. View Full-Text
Keywords: silver nanowires; nanomaterials; biocompatibility silver nanowires; nanomaterials; biocompatibility
Show Figures

Graphical abstract

MDPI and ACS Style

De Mori, A.; Jones, R.S.; Cretella, M.; Cerri, G.; Draheim, R.R.; Barbu, E.; Tozzi, G.; Roldo, M. Evaluation of Antibacterial and Cytotoxicity Properties of Silver Nanowires and Their Composites with Carbon Nanotubes for Biomedical Applications. Int. J. Mol. Sci. 2020, 21, 2303.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop