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Open AccessArticle

MYC-Associated Factor MAX is a Regulator of the Circadian Clock

1
Molecular Medicine Research Line, Fondazione Istituto Italiano di Tecnologia (IIT), 16135 Genoa, Italy
2
Center for Genomic Science, Fondazione Istituto Italiano di Tecnologia (IIT), 20139 Milan, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2294; https://doi.org/10.3390/ijms21072294 (registering DOI)
Received: 14 February 2020 / Revised: 17 March 2020 / Accepted: 24 March 2020 / Published: 26 March 2020
(This article belongs to the Section Molecular Biology)
The circadian transcriptional network is based on a competition between transcriptional activator and repressor complexes regulating the rhythmic expression of clock-controlled genes. We show here that the MYC-associated factor X, MAX, plays a repressive role in this network and operates through a MYC-independent binding to E-box-containing regulatory regions within the promoters of circadian BMAL1 targets. We further show that this “clock” function of MAX is required for maintaining a proper circadian rhythm and that MAX and BMAL1 contribute to two temporally alternating transcriptional complexes on clock-regulated promoters. We also identified MAX network transcriptional repressor, MNT, as a fundamental partner of MAX-mediated circadian regulation. Collectively, our data indicate that MAX regulates clock gene expression and contributes to keeping the balance between positive and negative elements of the molecular clock machinery. View Full-Text
Keywords: circadian clock; MYC-associated factor X; clock network; MAX network; MNT; BMAL1; cancer; MYC circadian clock; MYC-associated factor X; clock network; MAX network; MNT; BMAL1; cancer; MYC
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Blaževitš, O.; Bolshette, N.; Vecchio, D.; Guijarro, A.; Croci, O.; Campaner, S.; Grimaldi, B. MYC-Associated Factor MAX is a Regulator of the Circadian Clock. Int. J. Mol. Sci. 2020, 21, 2294.

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