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Open AccessArticle

Intramuscular Injection of Combined Calf Blood Compound (CFC) and Homeopathic Drug Tr14 Accelerates Muscle Regeneration In Vivo

Department of Orthopedics and Traumatology, University Medical Center of the Johannes Gutenberg University Mainz, 55122 Mainz, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(6), 2112; https://doi.org/10.3390/ijms21062112
Received: 27 January 2020 / Revised: 16 March 2020 / Accepted: 17 March 2020 / Published: 19 March 2020
Skeletal muscle injuries in competitive sports cause lengthy absences of athletes from tournaments. This is of tremendous competitive and economic relevance for both the athletes and their respective clubs. Therapy for structural muscle lesions aims to promote regeneration and fast-track return-to-play. A common clinical treatment strategy for muscle injuries is the intramuscular injection of calf blood compound and the homeopathic drug, Tr14. Although the combination of these two agents was reported to reduce recovery time, the regulatory mechanism whereby this occurs remains unknown. In this in vivo study, we selected a rat model of mechanical muscle injury to investigate the effect of this combination therapy on muscle regeneration. Gene expression analysis and histological images revealed that this combined intramuscular injection for muscle lesions can enhance the expression of pro-myogenic genes and proteins and accelerate muscle regeneration. These findings are novel and depict the positive effects of calf blood compound and the homeopathic drug, Tr14, which are utilized in the field of Sports medicine. View Full-Text
Keywords: muscle injury; calf blood compound; homeopathic drug; muscle regeneration; intramuscular injections muscle injury; calf blood compound; homeopathic drug; muscle regeneration; intramuscular injections
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MDPI and ACS Style

Belikan, P.; Nauth, L.; Färber, L.-C.; Abel, F.; Langendorf, E.; Drees, P.; Rommens, P.M.; Ritz, U.; Mattyasovszky, S.G. Intramuscular Injection of Combined Calf Blood Compound (CFC) and Homeopathic Drug Tr14 Accelerates Muscle Regeneration In Vivo. Int. J. Mol. Sci. 2020, 21, 2112. https://doi.org/10.3390/ijms21062112

AMA Style

Belikan P, Nauth L, Färber L-C, Abel F, Langendorf E, Drees P, Rommens PM, Ritz U, Mattyasovszky SG. Intramuscular Injection of Combined Calf Blood Compound (CFC) and Homeopathic Drug Tr14 Accelerates Muscle Regeneration In Vivo. International Journal of Molecular Sciences. 2020; 21(6):2112. https://doi.org/10.3390/ijms21062112

Chicago/Turabian Style

Belikan, Patrick; Nauth, Lisa; Färber, Lars-Christopher; Abel, Frédéric; Langendorf, Eva; Drees, Philipp; Rommens, Pol M.; Ritz, Ulrike; Mattyasovszky, Stefan G. 2020. "Intramuscular Injection of Combined Calf Blood Compound (CFC) and Homeopathic Drug Tr14 Accelerates Muscle Regeneration In Vivo" Int. J. Mol. Sci. 21, no. 6: 2112. https://doi.org/10.3390/ijms21062112

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