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Ion Channels in The Pathogenesis of Endometriosis: A Cutting-Edge Point of View

Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

Department of Medical and Surgical Specialties, Faculty of Medicine, Transilvania University of Brasov, 500019 Brasov, Romania
Department of Fundamental, Prophylactic and Clinical Sciences, Faculty of Medicine, University Transilvania Brasov, 500019 Brasov, Romania
Regina Maria Hospital, 500091 Brasov, Romania
“Victor Papilian” Medical School, University “Lucian Blaga” of Sibiu, 550024 Sibiu, Romania
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(5), 1750;
Received: 19 December 2019 / Revised: 27 February 2020 / Accepted: 2 March 2020 / Published: 4 March 2020
(This article belongs to the Special Issue Endometriosis Research: From Bench to Bedside)
Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millions of women of reproductive age. The lack of specific symptoms often determines a belated diagnosis. The gold standard remains invasive, surgery followed by a histopathological exam. A biomarker or a panel of biomarkers is easy to measure, usually noninvasive, and could benefit the clinician in both diagnosing and monitoring the treatment response. Several studies have advanced the idea of biomarkers for endometriosis, thereby circumventing unnecessary invasive techniques. Our paper aims at harmonizing the results of these studies in the search of promising perspectives on early diagnosis. Methods: We selected the papers from Google Academic, PubMed, and CrossRef and reviewed recent articles from the literature, aiming to evaluate the effectiveness of various putative serum and urinary biomarkers for endometriosis. Results: The majority of studies focused on a panel of biomarkers, rather than a single biomarker and were unable to identify a single biomolecule or a panel of biomarkers with sufficient specificity and sensitivity in endometriosis. Conclusion: Noninvasive biomarkers, proteomics, genomics, and miRNA microarray may aid the diagnosis, but further research on larger datasets along with a better understanding of the pathophysiologic mechanisms are needed. View Full-Text
Keywords: biomarker; angiogenesis; cytokines; urinary biomarkers; endometriosis biomarker; angiogenesis; cytokines; urinary biomarkers; endometriosis
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MDPI and ACS Style

Anastasiu, C.V.; Moga, M.A.; Elena Neculau, A.; Bălan, A.; Scârneciu, I.; Dragomir, R.M.; Dull, A.-M.; Chicea, L.-M. Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. Int. J. Mol. Sci. 2020, 21, 1750.

AMA Style

Anastasiu CV, Moga MA, Elena Neculau A, Bălan A, Scârneciu I, Dragomir RM, Dull A-M, Chicea L-M. Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives. International Journal of Molecular Sciences. 2020; 21(5):1750.

Chicago/Turabian Style

Anastasiu, Costin Vlad, Marius Alexandru Moga, Andrea Elena Neculau, Andreea Bălan, Ioan Scârneciu, Roxana Maria Dragomir, Ana-Maria Dull, and Liana-Maria Chicea. 2020. "Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives" International Journal of Molecular Sciences 21, no. 5: 1750.

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