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Endocrine-Disrupting Chemicals in Human Fetal Growth

Oestrogenic Endocrine Disruptors in the Placenta and the Fetus

by 1,†, 1,†, 2,3, 1 and 1,*
Beijing Key Laboratory for Animal Genetic Improvement, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics and Breeding of the Ministry of Agriculture, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences, Ministry of Health, Beijing 100021, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(4), 1519;
Received: 22 January 2020 / Revised: 20 February 2020 / Accepted: 20 February 2020 / Published: 23 February 2020
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals 2.0)
Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the stability and regulation of the endocrine system of the body or its offspring. These substances are generally stable in chemical properties, not easy to be biodegraded, and can be enriched in organisms. In the past half century, EDCs have gradually entered the food chain, and these substances have been frequently found in maternal blood. Perinatal maternal hormone levels are unstable and vulnerable to EDCs. Some EDCs can affect embryonic development through the blood-fetal barrier and cause damage to the neuroendocrine system, liver function, and genital development. Some also effect cross-generational inheritance through epigenetic mechanisms. This article mainly elaborates the mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health. View Full-Text
Keywords: placenta; fetus; estrogenic endocrine disruptors placenta; fetus; estrogenic endocrine disruptors
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MDPI and ACS Style

Tang, Z.-R.; Xu, X.-L.; Deng, S.-L.; Lian, Z.-X.; Yu, K. Oestrogenic Endocrine Disruptors in the Placenta and the Fetus. Int. J. Mol. Sci. 2020, 21, 1519.

AMA Style

Tang Z-R, Xu X-L, Deng S-L, Lian Z-X, Yu K. Oestrogenic Endocrine Disruptors in the Placenta and the Fetus. International Journal of Molecular Sciences. 2020; 21(4):1519.

Chicago/Turabian Style

Tang, Zi-Run, Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, and Kun Yu. 2020. "Oestrogenic Endocrine Disruptors in the Placenta and the Fetus" International Journal of Molecular Sciences 21, no. 4: 1519.

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