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Interleukin-17A and Keratinocytes in Psoriasis
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The Role of Th17-Related Cytokines in Atopic Dermatitis

Department of Dermatology, International University of Health and Welfare, Ichikawa Hospital, 6-1-14, Kounodai, Ichikawa, Chiba 272-0827, Japan
Int. J. Mol. Sci. 2020, 21(4), 1314; https://doi.org/10.3390/ijms21041314 (registering DOI)
Received: 25 January 2020 / Revised: 11 February 2020 / Accepted: 12 February 2020 / Published: 15 February 2020
(This article belongs to the Special Issue Therapy and Prevention of Atopic Dermatitis and Psoriasis)
T helper-17 (Th17) cells, which mainly produce IL-17, are associated with development of various autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and psoriasis. IL-17 and related cytokines are therapeutic targets of these diseases. In atopic dermatitis (AD), Th2 cytokines such as IL-4 and IL-13 are regarded to be the main player of the disease; however, Th17 cytokines are also expressed in AD skin lesions. Expression of IL-22 rather than IL-17 is predominant in AD skin, which is contrary to cytokine expression in psoriasis skin. Relatively low IL-17 expression in AD skin can induce relatively low antimicrobial peptide expression, which may be a reason why bacterial infection is frequently seen in AD patients. Failure of clinical trials for investigating the efficacy of anti-IL-12/23 p40 in AD has suggested that IL-17 expressed in skin lesions should not be the main player but a bystander responding to barrier dysfunction. View Full-Text
Keywords: IL-22; IL-26; subtypes of atopic dermatitis; ustekinumab; wound healing; antimicrobial peptides IL-22; IL-26; subtypes of atopic dermatitis; ustekinumab; wound healing; antimicrobial peptides
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Sugaya, M. The Role of Th17-Related Cytokines in Atopic Dermatitis. Int. J. Mol. Sci. 2020, 21, 1314.

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