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Bone Control of Muscle Function

Bone Physiopathology Unit, Genetics and Rare Diseases Research Area, Bambino Gesù Children’s Hospital, 00165 Rome, Italy
Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, 00151 Rome, Italy
Department of Clinical, Internal, Anesthetic and Cardiovascular Sciences, “Sapienza” University of Rome, 00151 Rome, Italy
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1178;
Received: 30 December 2019 / Revised: 21 January 2020 / Accepted: 7 February 2020 / Published: 11 February 2020
Bone and muscle represent a single functional system and are tightly connected to each other. Indeed, diseases characterized by alterations of muscle physiology have effects on bone remodeling and structure and vice versa. Muscle influence on bone has been deeply studied, and recent studies identified irisin as new molecule involved in this crosstalk. Muscle regulation by bone needs to be extensively investigated since in the last few years osteocalcin was recognized as a key molecule in the bone–muscle interaction. Osteocalcin can exist in two forms with different degrees of carboxylation. The undercarboxylated form of osteocalcin is a hormone released by the bone matrix during the osteoclast bone resorption and can bind its G-protein coupled receptor GPRC6A expressed in the muscle, thus regulating its function. Recently, this hormone was described as an antiaging molecule for its ability to regulate bone, muscle and cognitive functions. Indeed, the features of this bone-related hormone were used to test a new therapeutic approach for sarcopenia, since injection of osteocalcin in older mice induces the acquirement of physical abilities of younger animals. Even if this approach should be tested in humans, osteocalcin represents the most surprising molecule in endocrine regulation by the skeleton. View Full-Text
Keywords: bone; muscle; osteocalcin bone; muscle; osteocalcin
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MDPI and ACS Style

Battafarano, G.; Rossi, M.; Marampon, F.; Minisola, S.; Del Fattore, A. Bone Control of Muscle Function. Int. J. Mol. Sci. 2020, 21, 1178.

AMA Style

Battafarano G, Rossi M, Marampon F, Minisola S, Del Fattore A. Bone Control of Muscle Function. International Journal of Molecular Sciences. 2020; 21(4):1178.

Chicago/Turabian Style

Battafarano, Giulia, Michela Rossi, Francesco Marampon, Salvatore Minisola, and Andrea Del Fattore. 2020. "Bone Control of Muscle Function" International Journal of Molecular Sciences 21, no. 4: 1178.

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