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Open AccessArticle

A Unique Regulation Region in the 3′ UTR of HLA-G with a Promising Potential

The Concern Foundation Laboratories at the Lautenberg Center for Immunology and Cancer Research, The Biomedical Research Institute Israel Canada of the Faculty of Medicine, The Hebrew University Hadassah Medical School, The Hebrew University of Jerusalem, 9112001 Jerusalem, Israel
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 900;
Received: 29 December 2019 / Revised: 26 January 2020 / Accepted: 28 January 2020 / Published: 30 January 2020
(This article belongs to the Special Issue HLA-G: A New Target for Immune Checkpoint Inhibitors in Cancer?)
Human leukocyte antigen G (HLA-G) is a non-classical human leukocyte antigen (HLA) class I protein that interacts with inhibitory receptors and is commonly overexpressed in various cancers, thereby establishing itself as an inhibitory checkpoint immune ligand. It is also expressed in trophoblast cells during pregnancy and protects the fetus from immune rejection. Despite its crucial role and its intriguing expression pattern, the regulation of HLA-G’s expression is only partially understood. HLA-G’s mRNA is expressed in many tissues but the protein expression is restricted only to the cells mentioned above. Therefore, we suggest that HLA-G is post-transcriptionally regulated. Here, we reveal a distinctive site present only in the 3′ Untranslated region (UTR) of HLA-G, which might explain its unique expression pattern. Consequently, we attempted to find binding factors such as RNA binding proteins (RBPs) and microRNAS (miRs) that regulate HLA-G expression by interacting with this distinct site present in its 3′ UTR. Our research indicates that this site should be further studied in order to reveal its significance. View Full-Text
Keywords: HLA-G; RNA binding proteins; microRNA; 3′ UTR HLA-G; RNA binding proteins; microRNA; 3′ UTR
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Reches, A.; Berhani, O.; Mandelboim, O. A Unique Regulation Region in the 3′ UTR of HLA-G with a Promising Potential. Int. J. Mol. Sci. 2020, 21, 900.

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