Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging
Abstract
:1. Introduction
2. Antioxidative Effects of Melatonin
3. Reactive Oxygen and Reproductive Function
4. Melatonin in the Ovaries
5. The Clinical Application of Melatonin in the Field of Reproductive Medicine
5.1. Melatonin in Assisted Reproductive Technology (ART)
5.2. Oocyte Maturation, Embryo Development, and Melatonin
6. Reduced Fertility Associated with Ovarian Aging
7. Anti-Aging Effects of Melatonin
Author Contributions
Funding
Ethics Approval and Consent to Participate
Conflicts of Interest
References
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Patients | Number | Technique | Melatonin Treatment | Result | Mechanisms | Year | Author/Reference |
---|---|---|---|---|---|---|---|
infertile women | 115 (56M/59C) | IVF-ET | 3mg/day orally | improved fertilization rate | reduced 8-OHdG in FF increased M in FF | 2008 | Tamura [6] |
infertile women | 60 (30M/30C) | IVF-ET | 3mg/day orally | increased mature oocyte increased good quality embryos | 2011 | Eryilmaz [47] | |
infertile women | 85 (40M/45C) | IVF-ET | 3mg/day orally | increased mature oocyte increased good quality embryos | 2012 | Batioglu [46] | |
infertile women | 97 (97M/97C) | IVF, ICSI | 3mg/day orally | improved fertilization rate increased good quality embryos | 2014 | Nishihara [49] | |
infertile women diminished ovarian reserve | 66 (32M/24C) | IVF, ICSI | 3mg/day orally | increased mature oocyte increased good quality embryos | 2017 | Jahromi [48] | |
infertile women | 30 (10C/10M, 10M) | IVF, ICSI | 3 or 6mg/day orally | increased no of oocyte retrieved increased good quality embryos | increased M, TAC in FF decreased 8-OHdG in FF | 2019 | Espino [50] |
Animal | Design | Melatonin Treatment | Result | Year | Author/Reference |
---|---|---|---|---|---|
mouse | vitro COCs | 10−6 M | Cumulus expansion, M-Ⅱ ↑ ROS, Acetyla on level of H4k12 ↓ | 2017 | Keshavarzi Somayeh [51] |
mouse | vitro, IVM, implantation | 10−7 M | blastocyst rate, hatching blastocyst rate and blastocyst cell number ↑ pregnancy rate and birth rate↑, (ROS) production and cellular apoptosis ↓ | 2017 | Tian Xiuzhi [69] |
sheep | vitro, IVM | 10−7 M | rates of nuclear maturation, cumulus cells expansion, cleavage, and blastocyst ↑ MT1 and MT2 were expressed in oocytes, cumulus cells, and granulosa cells BMP15, PTX3, HAS2, EGFR ↑, cAMP level ↓, cGMP ↑ | 2017 | Tian Xiuzhi [65] |
bovine | vitro, IVM | 10−9 M | ROS↓, GSH↑,mitochondrial normal distribution increase ATP level upregulated ATPase 6, BMP-15, GDF-9, SOD-1, Gpx-4, and Bcl-2 downregulated apoptotic gene expression of caspase-3. | 2017 | Yang Minghui [68] |
porcine | vitro IVM COCs | 10−7, 10−6, 10−5 M | oocyte quality, embryo development ↑ ROS generation, apoptosis, and DNA damage ↓, GSX, OCT4, H2AX | 2018 | Lin Tao [52] |
bovine | vitro, IVM | 10−9 M | G1 blastocyst ↑, cell number ↑, apoptotic cell ↓ glutathione content, mitochondrial membrane potential ↑ antioxidant gene (SOD2) heat shock protein (HSPB1) ↑ | 2018 | Marques TC [53] |
porcine | vitro prolonged culture | 10−3 M | blastocyst rate↑ methylation at H3K4me2 and H3K27me2 ↓ imprinted gene NNAT ↓ | 2018 | Nie Junyu [71] |
bovine | vitro, IVM | 10−9 M | blastocyst, total cell number ↑, apoptotic cell ↓ ROS ↓, GSH ↑ caspase-3 ↓, BCL-2, XIAP, CAT, HSP70 ↑ | 2018 | Pang Yunwei [66] |
Goat | vitro, IVM | 10−9 M, 10−12 M | M-II stage, blastocyst ↑, GSH ↑, MTNR1A in cumulus cell and oocytes DNA methyltransferases (DNMTs) global DNA methylation ↓ | 2018 | Saeedabadi Saghar [63] |
mouse | vitro, IVM | 10 μM | fertilization rate ↑ hyaluronan synthase-2 (HAS2) and Progesterone receptor (PGR) ↑ | 2018 | Ezzati Maryam [70] |
porcine | vitro COCs | 10−9 M | blastocyst, cell number, cumulus expansion ↑, apoptosis ↓ MT2 was expressed in both oocytes and cumulus cells M effects were abolished when either luzindole or 4P-PDOT (MT antagonist) | 2018 | Lee Sanghoon [62] |
porcine | vitro COCs | 10−9 M | pro-apoptotic protein BimEL, ERK-mediated phosphorylation M only promoted the ubiquitination of phosphorylated BimEL M action was independent of its receptor and its antioxidant properties | 2018 | Wang Yingzheng [67] |
bovine | vitro cloned embryo | 10−9 M | cloned embryo development ↑ oxidative stress, apoptosis, mitochondria, chromosome alignment epigenetic modifications, H3K9 acetylation ↑, H3K9 methylation ↓ | 2019 | An Quanli [56] |
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Tamura, H.; Jozaki, M.; Tanabe, M.; Shirafuta, Y.; Mihara, Y.; Shinagawa, M.; Tamura, I.; Maekawa, R.; Sato, S.; Taketani, T.; et al. Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. Int. J. Mol. Sci. 2020, 21, 1135. https://doi.org/10.3390/ijms21031135
Tamura H, Jozaki M, Tanabe M, Shirafuta Y, Mihara Y, Shinagawa M, Tamura I, Maekawa R, Sato S, Taketani T, et al. Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging. International Journal of Molecular Sciences. 2020; 21(3):1135. https://doi.org/10.3390/ijms21031135
Chicago/Turabian StyleTamura, Hiroshi, Mai Jozaki, Manabu Tanabe, Yuichiro Shirafuta, Yumiko Mihara, Masahiro Shinagawa, Isao Tamura, Ryo Maekawa, Shun Sato, Toshiaki Taketani, and et al. 2020. "Importance of Melatonin in Assisted Reproductive Technology and Ovarian Aging" International Journal of Molecular Sciences 21, no. 3: 1135. https://doi.org/10.3390/ijms21031135