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Article

ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles

1
The Smart Materials Research Institute, Southern Federal University, Sladkova Street 178/24, 344090 Rostov-on-Don, Russia
2
Research Laboratory “Biomedicine”, Southern Federal University, Stachki av. 194/1, 344090 Rostov-on-Don, Russia
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(24), 9758; https://doi.org/10.3390/ijms21249758
Received: 13 November 2020 / Revised: 13 December 2020 / Accepted: 17 December 2020 / Published: 21 December 2020
(This article belongs to the Special Issue Self-Assembled Polymer Nanoparticles for Tumor Imaging and Therapy)
Synthesis of the MIL-100 metal-organic framework particles was carried out by hydrothermal (HT) and microwave (MW)-assisted methods. Transmission electron microscopy showed formation of microparticles in the course of hydrothermal synthesis and nanoparticles for microwave-assisted synthesis. Powder X-ray diffraction confirmed formation of larger crystallites for hydrothermal synthesis. Particle aggregation in aqueous solution was observed by dynamic light scattering. However, the stability of both samples could be improved in acetic acid solution. Nitrogen sorption isotherms showed high porosity of the particles. ᶫ-leucine molecule was used as a model molecule for loading in the porous micro- and nanoparticles. Loading was estimated by FTIR spectroscopy and thermogravimetric analysis. UV-VIS spectroscopy quantified ᶫ-leucine release from the particles in aqueous solution. Cytotoxicity studies using the HeLa cell model showed that the original particles were somewhat toxic, but ᶫ-leucine loading ameliorated the toxic effects, likely due to signaling properties of the amino acid. View Full-Text
Keywords: MOF nanoparticles; MIL-100; targeted drug delivery; leucine; nanomedicine MOF nanoparticles; MIL-100; targeted drug delivery; leucine; nanomedicine
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MDPI and ACS Style

Gorban, I.E.; Soldatov, M.A.; Butova, V.V.; Medvedev, P.V.; Burachevskaya, O.A.; Belanova, A.; Zolotukhin, P.; Soldatov, A.V. ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles. Int. J. Mol. Sci. 2020, 21, 9758. https://doi.org/10.3390/ijms21249758

AMA Style

Gorban IE, Soldatov MA, Butova VV, Medvedev PV, Burachevskaya OA, Belanova A, Zolotukhin P, Soldatov AV. ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles. International Journal of Molecular Sciences. 2020; 21(24):9758. https://doi.org/10.3390/ijms21249758

Chicago/Turabian Style

Gorban, Ivan E., Mikhail A. Soldatov, Vera V. Butova, Pavel V. Medvedev, Olga A. Burachevskaya, Anna Belanova, Peter Zolotukhin, and Alexander V. Soldatov 2020. "ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles" International Journal of Molecular Sciences 21, no. 24: 9758. https://doi.org/10.3390/ijms21249758

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