Next Article in Journal
Clinical Application of Bone Marrow Mesenchymal Stem/Stromal Cells to Repair Skeletal Tissue
Next Article in Special Issue
Targeted Nanoparticles Harboring Jasmine-Oil-Entrapped Paclitaxel for Elimination of Lung Cancer Cells
Previous Article in Journal
Glyceraldehyde-3-Phosphate Dehydrogenase Increases the Adhesion of Lactobacillus reuteri to Host Mucin to Enhance Probiotic Effects
Previous Article in Special Issue
Chlorin e6-Loaded PEG-PCL Nanoemulsion for Photodynamic Therapy and In Vivo Drug Delivery

ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles

The Smart Materials Research Institute, Southern Federal University, Sladkova Street 178/24, 344090 Rostov-on-Don, Russia
Research Laboratory “Biomedicine”, Southern Federal University, Stachki av. 194/1, 344090 Rostov-on-Don, Russia
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(24), 9758;
Received: 13 November 2020 / Revised: 13 December 2020 / Accepted: 17 December 2020 / Published: 21 December 2020
(This article belongs to the Special Issue Self-Assembled Polymer Nanoparticles for Tumor Imaging and Therapy)
Synthesis of the MIL-100 metal-organic framework particles was carried out by hydrothermal (HT) and microwave (MW)-assisted methods. Transmission electron microscopy showed formation of microparticles in the course of hydrothermal synthesis and nanoparticles for microwave-assisted synthesis. Powder X-ray diffraction confirmed formation of larger crystallites for hydrothermal synthesis. Particle aggregation in aqueous solution was observed by dynamic light scattering. However, the stability of both samples could be improved in acetic acid solution. Nitrogen sorption isotherms showed high porosity of the particles. ᶫ-leucine molecule was used as a model molecule for loading in the porous micro- and nanoparticles. Loading was estimated by FTIR spectroscopy and thermogravimetric analysis. UV-VIS spectroscopy quantified ᶫ-leucine release from the particles in aqueous solution. Cytotoxicity studies using the HeLa cell model showed that the original particles were somewhat toxic, but ᶫ-leucine loading ameliorated the toxic effects, likely due to signaling properties of the amino acid. View Full-Text
Keywords: MOF nanoparticles; MIL-100; targeted drug delivery; leucine; nanomedicine MOF nanoparticles; MIL-100; targeted drug delivery; leucine; nanomedicine
Show Figures

Figure 1

MDPI and ACS Style

Gorban, I.E.; Soldatov, M.A.; Butova, V.V.; Medvedev, P.V.; Burachevskaya, O.A.; Belanova, A.; Zolotukhin, P.; Soldatov, A.V. ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles. Int. J. Mol. Sci. 2020, 21, 9758.

AMA Style

Gorban IE, Soldatov MA, Butova VV, Medvedev PV, Burachevskaya OA, Belanova A, Zolotukhin P, Soldatov AV. ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles. International Journal of Molecular Sciences. 2020; 21(24):9758.

Chicago/Turabian Style

Gorban, Ivan E., Mikhail A. Soldatov, Vera V. Butova, Pavel V. Medvedev, Olga A. Burachevskaya, Anna Belanova, Peter Zolotukhin, and Alexander V. Soldatov 2020. "ᶫ-Leucine Loading and Release in MIL-100 Nanoparticles" International Journal of Molecular Sciences 21, no. 24: 9758.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop