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Review

Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy

1
EA 2160 Mer Molécules Santé, Le Mans Université, F-72085 Le Mans, France
2
UMR 6286 CNRS Unité Fonctionnalité et Ingénierie des Protéines, Université de Nantes, F-44000 Nantes, France
3
UMR 7355 CNRS Immunologie et Neurogénétique Expérimentales et Moléculaires, F-45071 Orléans, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9273; https://doi.org/10.3390/ijms21239273
Received: 23 October 2020 / Revised: 1 December 2020 / Accepted: 2 December 2020 / Published: 4 December 2020
(This article belongs to the Special Issue Microalgal Molecules and Enzymes)
Fucoxanthin is a well-known carotenoid of the xanthophyll family, mainly produced by marine organisms such as the macroalgae of the fucus genus or microalgae such as Phaeodactylum tricornutum. Fucoxanthin has antioxidant and anti-inflammatory properties but also several anticancer effects. Fucoxanthin induces cell growth arrest, apoptosis, and/or autophagy in several cancer cell lines as well as in animal models of cancer. Fucoxanthin treatment leads to the inhibition of metastasis-related migration, invasion, epithelial–mesenchymal transition, and angiogenesis. Fucoxanthin also affects the DNA repair pathways, which could be involved in the resistance phenotype of tumor cells. Moreover, combined treatments of fucoxanthin, or its metabolite fucoxanthinol, with usual anticancer treatments can support conventional therapeutic strategies by reducing drug resistance. This review focuses on the current knowledge of fucoxanthin with its potential anticancer properties, showing that fucoxanthin could be a promising compound for cancer therapy by acting on most of the classical hallmarks of tumor cells. View Full-Text
Keywords: angiogenesis; apoptosis; cancer; cell growth arrest; DNA repair; EMT; fucoxanthin; inflammation; invasion; migration angiogenesis; apoptosis; cancer; cell growth arrest; DNA repair; EMT; fucoxanthin; inflammation; invasion; migration
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MDPI and ACS Style

Méresse, S.; Fodil, M.; Fleury, F.; Chénais, B. Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy. Int. J. Mol. Sci. 2020, 21, 9273. https://doi.org/10.3390/ijms21239273

AMA Style

Méresse S, Fodil M, Fleury F, Chénais B. Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy. International Journal of Molecular Sciences. 2020; 21(23):9273. https://doi.org/10.3390/ijms21239273

Chicago/Turabian Style

Méresse, Sarah, Mostefa Fodil, Fabrice Fleury, and Benoît Chénais. 2020. "Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy" International Journal of Molecular Sciences 21, no. 23: 9273. https://doi.org/10.3390/ijms21239273

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