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Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies

Department of Laboratory Medicine, Translational Cancer Research, Faculty of Medicine, Lund University, 22381 Lund, Sweden
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Int. J. Mol. Sci. 2020, 21(23), 9203; https://doi.org/10.3390/ijms21239203
Received: 16 November 2020 / Revised: 30 November 2020 / Accepted: 1 December 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Protein Kinases: Function, Substrates, and Implication in Diseases)
The Wnt signalling pathway is a central communication cascade between cells to orchestrate polarity and fate during development and adult tissue homeostasis in various organisms. This pathway can be regulated by different signalling molecules in several steps. One of the coordinators in this pathway is Nemo-like kinase (NLK), which is an atypical proline-directed serine/threonine mitogen-activated protein (MAP) kinase. Very recently, NLK was established as an essential regulator in different cellular processes and abnormal NLK expression was highlighted to affect the development and progression of various diseases. In this review, we focused on the recent discoveries by using NLK-deficient mice, which show a phenotype in the development and function of organs such as the lung, heart and skeleton. Furthermore, NLK could conduct the function and differentiation of cells from the immune system, in addition to regulating neurodegenerative diseases, such as Huntington’s disease and spinocerebellar ataxias. Overall, generations of NLK-deficient mice have taught us valuable lessons about the role of this kinase in certain diseases and development. View Full-Text
Keywords: Nemo-like kinase (NLK); animal models; mice; development; immune system neuronal disorders Nemo-like kinase (NLK); animal models; mice; development; immune system neuronal disorders
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MDPI and ACS Style

Daams, R.; Massoumi, R. Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies. Int. J. Mol. Sci. 2020, 21, 9203. https://doi.org/10.3390/ijms21239203

AMA Style

Daams R, Massoumi R. Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies. International Journal of Molecular Sciences. 2020; 21(23):9203. https://doi.org/10.3390/ijms21239203

Chicago/Turabian Style

Daams, Renée, and Ramin Massoumi. 2020. "Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies" International Journal of Molecular Sciences 21, no. 23: 9203. https://doi.org/10.3390/ijms21239203

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