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Review

Engineering Bacterial Cellulose by Synthetic Biology

by
Amritpal Singh
1,2,
Kenneth T. Walker
1,2,
Rodrigo Ledesma-Amaro
1,2 and
Tom Ellis
1,2,*
1
Imperial College Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, UK
2
Department of Bioengineering, Imperial College London, London SW7 2AZ, UK
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9185; https://doi.org/10.3390/ijms21239185
Submission received: 11 November 2020 / Revised: 26 November 2020 / Accepted: 28 November 2020 / Published: 2 December 2020
(This article belongs to the Special Issue Bacterial Cellulose: Synthesis, Structure, and Biomedical Applications)
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Abstract

Synthetic biology is an advanced form of genetic manipulation that applies the principles of modularity and engineering design to reprogram cells by changing their DNA. Over the last decade, synthetic biology has begun to be applied to bacteria that naturally produce biomaterials, in order to boost material production, change material properties and to add new functionalities to the resulting material. Recent work has used synthetic biology to engineer several Komagataeibacter strains; bacteria that naturally secrete large amounts of the versatile and promising material bacterial cellulose (BC). In this review, we summarize how genetic engineering, metabolic engineering and now synthetic biology have been used in Komagataeibacter strains to alter BC, improve its production and begin to add new functionalities into this easy-to-grow material. As well as describing the milestone advances, we also look forward to what will come next from engineering bacterial cellulose by synthetic biology.
Keywords: bacterial cellulose; synthetic biology; metabolic engineering; biomaterials bacterial cellulose; synthetic biology; metabolic engineering; biomaterials

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MDPI and ACS Style

Singh, A.; Walker, K.T.; Ledesma-Amaro, R.; Ellis, T. Engineering Bacterial Cellulose by Synthetic Biology. Int. J. Mol. Sci. 2020, 21, 9185. https://doi.org/10.3390/ijms21239185

AMA Style

Singh A, Walker KT, Ledesma-Amaro R, Ellis T. Engineering Bacterial Cellulose by Synthetic Biology. International Journal of Molecular Sciences. 2020; 21(23):9185. https://doi.org/10.3390/ijms21239185

Chicago/Turabian Style

Singh, Amritpal, Kenneth T. Walker, Rodrigo Ledesma-Amaro, and Tom Ellis. 2020. "Engineering Bacterial Cellulose by Synthetic Biology" International Journal of Molecular Sciences 21, no. 23: 9185. https://doi.org/10.3390/ijms21239185

APA Style

Singh, A., Walker, K. T., Ledesma-Amaro, R., & Ellis, T. (2020). Engineering Bacterial Cellulose by Synthetic Biology. International Journal of Molecular Sciences, 21(23), 9185. https://doi.org/10.3390/ijms21239185

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