Isocyanide Multicomponent Reactions on Solid Phase: State of the Art and Future Application

Round 1

Reviewer 1 Report

This is an almost perfect review!

Possible improvement in several reaction schemes: The formula of the following aldehydes should be redrawn with a longer single bond between the substituent (R¹, R² etc.)  and the formyl carbon atom: 11, 18, 93, 113, 125, 135, 141, 147, 154, 163, 168, 185, 209, 215, 227, 248, 254, 259, 277, 287, 296, 317, 323, 388, 401, 405, 409, 419, 424, 430, 435, 456, and 459.

See attached PDF document produced with ChemDraw.

Comments for author File: Comments.pdf

Author Response

Reviewer 1

Possible improvement in several reaction schemes: The formula of the following aldehydes should be redrawn with a longer single bond between the substituent (R¹, R² etc.)  and the formyl carbon atom: 11, 18, 93, 113, 125, 135, 141, 147, 154, 163, 168, 185, 209, 215, 227, 248, 254, 259, 277, 287, 296, 317, 323, 388, 401, 405, 409, 419, 424, 430, 435, 456, and 459.

Response:

The formula of the following aldehydes was redrawn with a longer single bond between the R substituent and the formyl carbon:

• Structure 11 in Scheme 1, line 81
• Structure 18 in Scheme 2, line 88
• Structure 93 in Scheme 19, line 356
• Structure 113 in Scheme 24, line 404
• Structure 125 in Scheme 26, line 433
• Structure 135 in Scheme 28, line 448
• Structure 141 in Scheme 29, line 466
• Structure 147 in Scheme 30, line 479
• Structure 154 in Scheme 31, line 494
• Structure 163 in Scheme 32, line 511
• Structure 168 in Scheme 33, line 520
• Structure 185 in Scheme 36, line 556
• Structure 209 in Scheme 37, line 581
• Structure 215 in Scheme 38, line 593
• Structure 227 in Scheme 40, line 614
• Structure 248 in Scheme 43, line 653
• Structure 254 in Scheme 44, line 659
• Structure 259 in Scheme 45, line 668
• Structure 277 in Scheme 48, line 713
• Structure 287 in Scheme 49, line 727
• Structure 296 in Scheme 50, line 741
• Structure 317 in Scheme 52, line 768
• Structure 323 in Scheme 53, line 780
• Structure 18 in Scheme 54, line 796
• Structure 388 in Scheme 65, line 918
• Structure 401 in Scheme 67, line 937
• Structure 405 in Scheme 68, line 942
• Structure 409 in Scheme 69, line 953
• Structure 419 in Scheme 71, line 967
• Structure 424 in Scheme 72, line 987
• Structure 430 in Scheme 73, line 998
• Structure 435 in Scheme 74, line 1006
• Structure 456 in Scheme 77, line 1057
• Structure 459 in Scheme 78, line 1066

Reviewer 2 Report

The authors have well described about the solid-phase syntheses of heterocycles involving isocyanide-based multicomponent reactions in this review. Though there are lot of reviews reported on MCRs, the present review has it own contribution towards the solid-phase applications of IMCRs. I would like to request the honorable editor to accept the review in its present form.

Author Response

Reviewer 2

No changes were requested.