Next Article in Journal
Tropinone-Derived Alkaloids as Potent Anticancer Agents: Synthesis, Tyrosinase Inhibition, Mechanism of Action, DFT Calculation, and Molecular Docking Studies
Next Article in Special Issue
Curcumin Metabolite Tetrahydrocurcumin in the Treatment of Eye Diseases
Previous Article in Journal
Adipokines in the Skin and in Dermatological Diseases
Previous Article in Special Issue
Rapha Myr®, a Blend of Sulforaphane and Myrosinase, Exerts Antitumor and Anoikis-Sensitizing Effects on Human Astrocytoma Cells Modulating Sirtuins and DNA Methylation
Open AccessReview

Natural Salicylates and Their Roles in Human Health

Department of Plant Medicals, Andong National University, Andong 36729, Korea
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9049; https://doi.org/10.3390/ijms21239049
Received: 31 October 2020 / Revised: 25 November 2020 / Accepted: 26 November 2020 / Published: 28 November 2020
(This article belongs to the Special Issue Biological Properties of Secondary Metabolites and Natural Compounds)
Salicylic acid (SA) is a plant hormone which plays a crucial role in the plant defense against various pathogens and abiotic stresses. Increasing reports suggest that this phenolic compound and its derivatives, collectively termed salicylates, not only regulate plant defense but also have beneficial effects on human health. Both natural and synthetic salicylates are known to have multiple targets in humans, thereby exhibiting various appreciating pharmacological roles, including anti-inflammatory, anticancer, neuroprotective, antidiabetic effects, and so on. The role of some salicylates, such as acetylsalicylic acid (aspirin), 5-aminosalicylic acid (mesalazine), and amorfrutins in human diseases has been well studied in vitro. However, their clinical significance in different diseases is largely unknown. Based on recent studies, five natural salicylates, including amorfrutin, ginkgolic acid, grifolic acid, tetrahydrocannabinolic acid, and cannabidiolic acid, showed potential roles in different challenging human diseases. This review summarizes together some of the recent information on multitarget regulatory activities of these natural salicylates and their pharmacological roles in human health. View Full-Text
Keywords: salicylates; pharmacological role; amorfrutin; ginkgolic acid; grifolic acid; tetrahydrocannabinolic acid; cannabidiolic acid salicylates; pharmacological role; amorfrutin; ginkgolic acid; grifolic acid; tetrahydrocannabinolic acid; cannabidiolic acid
Show Figures

Figure 1

MDPI and ACS Style

Yeasmin, F.; Choi, H.W. Natural Salicylates and Their Roles in Human Health. Int. J. Mol. Sci. 2020, 21, 9049. https://doi.org/10.3390/ijms21239049

AMA Style

Yeasmin F, Choi HW. Natural Salicylates and Their Roles in Human Health. International Journal of Molecular Sciences. 2020; 21(23):9049. https://doi.org/10.3390/ijms21239049

Chicago/Turabian Style

Yeasmin, Fatema; Choi, Hyong W. 2020. "Natural Salicylates and Their Roles in Human Health" Int. J. Mol. Sci. 21, no. 23: 9049. https://doi.org/10.3390/ijms21239049

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop