Next Article in Journal
Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer
Next Article in Special Issue
A Review of Murine Cytomegalovirus as a Model for Human Cytomegalovirus Disease—Do Mice Lie?
Previous Article in Journal
Taurine Attenuates Catabolic Processes Related to the Onset of Sarcopenia
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 21
Issue 22
10.3390/ijms21228864
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV)

by
Samantha Barnes
1,2,
Ophelia Schilizzi
1,2,
Katherine M. Audsley
1,2,
Hannah V. Newnes
1,2 and
Bree Foley
1,*
1
Telethon Kids Institute, University of Western Australia, Perth Children’s Hospital, Nedlands, WA 6009, Australia
2
School of Biomedical Sciences, The University of Western Australia, Crawley, WA 6009, Australia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8864; https://doi.org/10.3390/ijms21228864
Submission received: 28 October 2020 / Revised: 20 November 2020 / Accepted: 20 November 2020 / Published: 23 November 2020
(This article belongs to the Special Issue Unravelling the Mysteries of Cytomegalovirus)
Browse Figures
Versions Notes

Abstract

Natural killer (NK) cells play a significant and vital role in the first line of defense against infection through their ability to target cells without prior sensitization. They also contribute significantly to the activation and recruitment of both innate and adaptive immune cells through the production of a range of cytokines and chemokines. In the context of cytomegalovirus (CMV) infection, NK cells and CMV have co-evolved side by side to employ several mechanisms to evade one another. However, during this co-evolution the discovery of a subset of long-lived NK cells with enhanced effector potential, increased antibody-dependent responses and the potential to mediate immune memory has revolutionized the field of NK cell biology. The ability of a virus to imprint on the NK cell receptor repertoire resulting in the expansion of diverse, highly functional NK cells to this day remains a significant immunological phenomenon that only occurs in the context of CMV. Here we review our current understanding of the development of these NK cells, commonly referred to as adaptive NK cells and their current role in transplantation, infection, vaccination and cancer immunotherapy to decipher the complex role of CMV in dictating NK cell functional fate.
Keywords: natural killer cells; cytomegalovirus; viral infection; transplantation; vaccination; cancer immunotherapy natural killer cells; cytomegalovirus; viral infection; transplantation; vaccination; cancer immunotherapy
Graphical Abstract

Share and Cite

MDPI and ACS Style

Barnes, S.; Schilizzi, O.; Audsley, K.M.; Newnes, H.V.; Foley, B. Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV). Int. J. Mol. Sci. 2020, 21, 8864. https://doi.org/10.3390/ijms21228864

AMA Style

Barnes S, Schilizzi O, Audsley KM, Newnes HV, Foley B. Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV). International Journal of Molecular Sciences. 2020; 21(22):8864. https://doi.org/10.3390/ijms21228864

Chicago/Turabian Style

Barnes, Samantha, Ophelia Schilizzi, Katherine M. Audsley, Hannah V. Newnes, and Bree Foley. 2020. "Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV)" International Journal of Molecular Sciences 21, no. 22: 8864. https://doi.org/10.3390/ijms21228864

APA Style

Barnes, S., Schilizzi, O., Audsley, K. M., Newnes, H. V., & Foley, B. (2020). Deciphering the Immunological Phenomenon of Adaptive Natural Killer (NK) Cells and Cytomegalovirus (CMV). International Journal of Molecular Sciences, 21(22), 8864. https://doi.org/10.3390/ijms21228864

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop