New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis
1
Department of Nephrology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark
2
Department of Nephrology, Herlev Hospital, University of Copenhagen, 2730 Herlev, Denmark
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(22), 8810; https://doi.org/10.3390/ijms21228810
Received: 28 October 2020
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Revised: 16 November 2020
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Accepted: 19 November 2020
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Published: 20 November 2020
(This article belongs to the Special Issue Regulation of Bone Mineral Homeostasis)
The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the three hormones. The present review summarizes the complex regulation of FGF23 and the disturbed FGF23/Klotho system in chronic kidney disease (CKD). In addition to the reduced ability of the injured kidney to regulate plasma levels of FGF23, several CKD-related factors have been shown to stimulate FGF23 production. The high circulating FGF23 levels have detrimental effects on erythropoiesis, the cardio-vascular system and the immune system, all contributing to the disturbed system biology in CKD. Moreover, new factors secreted by the injured kidney and the uremic calcified vasculature play a role in the mineral and bone disorder in CKD and create a vicious pathological crosstalk.
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Keywords:
acute kidney failure; chronic kidney failure; calcium; phosphate; klotho; PTH; calcitriol; activin A; CKD-MBD; circadian rhythm; bone; crosstalk
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MDPI and ACS Style
Mace, M.L.; Olgaard, K.; Lewin, E. New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis. Int. J. Mol. Sci. 2020, 21, 8810. https://doi.org/10.3390/ijms21228810
AMA Style
Mace ML, Olgaard K, Lewin E. New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis. International Journal of Molecular Sciences. 2020; 21(22):8810. https://doi.org/10.3390/ijms21228810
Chicago/Turabian StyleMace, Maria L., Klaus Olgaard, and Ewa Lewin. 2020. "New Aspects of the Kidney in the Regulation of Fibroblast Growth Factor 23 (FGF23) and Mineral Homeostasis" International Journal of Molecular Sciences 21, no. 22: 8810. https://doi.org/10.3390/ijms21228810
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