Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer
Abstract
:1. Introduction: A General Overview of Ca2+ Signaling
2. Ca2+ Homeostasis during Cell Cycle and Tumor Growth
3. Role of Ca2+ in Apoptosis and Cancer
4. The Regulation of Autophagy by Calcium Signals and Its Involvement in Cancer
5. New Strategies for Ca2+ Signaling in Cancer Therapy: Ca2+ Channels and Pumps as Targets
5.1. TRP Channels
5.2. VGCCs and Purinergic P2 Receptors
5.3. SOCE Machinery Proteins (ORAI and STIM)
5.4. IP3Rs and Ca2+-ATPases
5.5. MCU and VDAC
6. Plan of Action in Cancer Therapy: Intersection between Cancer Therapies with Ca2+ Signaling
7. Discussion
Author Contributions
Funding
Conflicts of Interest
Abbreviations
AMPK | 5′ adenosine monophosphate-activated protein kinase |
APs | autophagosomes |
ATG | autophagy-related |
BAP1 | BRCA1-associated protein 1 |
BCL-2 | B-cell lymphoma 2 |
BECN1 | coiled-coil, moesin-like BCL2 interacting protein |
Ca2+ | calcium |
Cyt-C | cytochrome C |
CAM | calmodulin |
CAMK | Ca2+/Calmodulin Dependent Protein Kinases |
CaN | calcineurin |
CDK | cyclin-dependent protein kinases |
DISC | death-inducing signaling complex |
ER | endoplasmic reticulum |
HVA | high voltage activated |
IP3Rs | inositol 1,4,5-triphosphate receptors |
LC3 | microtubule-associated proteins 1A/1B light chain 3 |
LVA | low voltage activated |
MAMs | mitochondria associated membranes |
MAPK | mitogen-activated protein kinase |
MCU | mitochondrial calcium uniporter |
MPT | mitochondrial permeability transition |
mTOR | mammalian target of rapamycin |
NCX | Na+/Ca2+ exchanger |
NFAT | nuclear factor of activated T-cell |
NMDA | N-methyl-d-aspartate receptor |
PCD | programmed cell death |
PD-1 | programmed death-1 |
PI3K | phosphatidylinositol 3-kinase |
PI3P | phosphatidylinositol-3-phosphate |
PM | plasma membrane |
PMCA | plasma membrane Ca2+ transport ATPase |
PML | promyelocytic leukemia protein |
PTEN | protein phosphatase and tensin homolog |
RHEB | RAS homolog enriched in brain |
RIPK | receptor-interacting serine/threonine-protein kinase |
RyRs | ryanodine receptors |
SERCA | sarcoendoplasmic reticulum Ca2+-ATPase |
SOCE | store-operated Ca2+ entry |
SPCA | secretory protein calcium ATPase |
TFEB | transcription factor EB |
TIL | tumor-infiltrating T lymphocytes |
TRPML1 | transient receptor potential mucolipin 1 |
TRPC | transient receptor channels |
ULK | Unc-51 like autophagy activating kinase |
V-ATPase | vacuolar-type ATPase |
VDAC | Voltage-dependent anion channels |
VGCC | voltage-gated Ca2+ channels |
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Channel/Transporter/Pump | Compound | Cancer |
---|---|---|
TRPCs | 20-GPPD | Colorectal |
SKF96365 | Glioblastoma | |
Carvacrol | Glioma | |
D-3263 | Prostate, colon, breast, lung, pancreas, leiomyosarcoma, and Kaposi’s sarcoma | |
Capsaicin | Prostate | |
Cannabidiol | Bladder | |
SOR-C13 | Ovarian and prostate | |
Dexamethasone | Leukemia | |
VGGCs | Mibefradil | Esophageal, colon, glioblastoma, and ovarian |
NNC-55-096 | Glioblastoma and ovarian | |
Purinergic P2 receptors | BIL010t | Basal cell carcinoma |
BIL06v | Advanced or metastatic solid tumors | |
AR-C118925XX | Pancreatic ductal adenocarcinoma | |
ORAI and STIM | SKF96365 | Breast |
DPB-162AE/-163AE | Colon and glioma | |
ML-9 | Prostate | |
GA101/obinutuzumab | Non-Hodgkin lymphoma and leukemia | |
5-Fluorouracil | Hepatocarcinoma | |
SERCA | Mipsargargin | Prostate cancers, glioblastoma, kidney, and hepatocellular carcinoma |
Curcumin | Breast, lung, ovarian, and colon | |
PMCA | Pt(O,O0-acac)(γ-acac)(DMS) | Breast |
Resveratrol | Prostate | |
IP3R3 | Paclitaxel | Ovarian, breast, neck and head |
VDAC | R-Tf-D-LP4 | Glioblastoma, lung, and breast |
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Patergnani, S.; Danese, A.; Bouhamida, E.; Aguiari, G.; Previati, M.; Pinton, P.; Giorgi, C. Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer. Int. J. Mol. Sci. 2020, 21, 8323. https://doi.org/10.3390/ijms21218323
Patergnani S, Danese A, Bouhamida E, Aguiari G, Previati M, Pinton P, Giorgi C. Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer. International Journal of Molecular Sciences. 2020; 21(21):8323. https://doi.org/10.3390/ijms21218323
Chicago/Turabian StylePatergnani, Simone, Alberto Danese, Esmaa Bouhamida, Gianluca Aguiari, Maurizio Previati, Paolo Pinton, and Carlotta Giorgi. 2020. "Various Aspects of Calcium Signaling in the Regulation of Apoptosis, Autophagy, Cell Proliferation, and Cancer" International Journal of Molecular Sciences 21, no. 21: 8323. https://doi.org/10.3390/ijms21218323