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Article

Effects of Estrogen Receptor and Wnt Signaling Activation on Mechanically Induced Bone Formation in a Mouse Model of Postmenopausal Bone Loss

1
Institute of Orhopedic Research and Biomechanics, Trauma Research Center Ulm, University Medical Center Ulm, 89081 Ulm, Germany
2
Orthopaedic Center for Musculoskeletal Research, University of Würzburg, 97074 Würzburg, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to the study.
Int. J. Mol. Sci. 2020, 21(21), 8301; https://doi.org/10.3390/ijms21218301
Received: 14 September 2020 / Revised: 30 October 2020 / Accepted: 31 October 2020 / Published: 5 November 2020
(This article belongs to the Special Issue Bone Development and Regeneration)
In the adult skeleton, bone remodeling is required to replace damaged bone and functionally adapt bone mass and structure according to the mechanical requirements. It is regulated by multiple endocrine and paracrine factors, including hormones and growth factors, which interact in a coordinated manner. Because the response of bone to mechanical signals is dependent on functional estrogen receptor (ER) and Wnt/β-catenin signaling and is impaired in postmenopausal osteoporosis by estrogen deficiency, it is of paramount importance to elucidate the underlying mechanisms as a basis for the development of new strategies in the treatment of osteoporosis. The present study aimed to investigate the effectiveness of the activation of the ligand-dependent ER and the Wnt/β-catenin signal transduction pathways on mechanically induced bone formation using ovariectomized mice as a model of postmenopausal bone loss. We demonstrated that both pathways interact in the regulation of bone mass adaption in response to mechanical loading and that the activation of Wnt/β-catenin signaling considerably increased mechanically induced bone formation, whereas the effects of estrogen treatment strictly depended on the estrogen status in the mice. View Full-Text
Keywords: bone remodeling; mechanotransduction; ER signaling; Wnt/β-catenin signaling; ovariectomy bone remodeling; mechanotransduction; ER signaling; Wnt/β-catenin signaling; ovariectomy
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MDPI and ACS Style

Liedert, A.; Nemitz, C.; Haffner-Luntzer, M.; Schick, F.; Jakob, F.; Ignatius, A. Effects of Estrogen Receptor and Wnt Signaling Activation on Mechanically Induced Bone Formation in a Mouse Model of Postmenopausal Bone Loss. Int. J. Mol. Sci. 2020, 21, 8301. https://doi.org/10.3390/ijms21218301

AMA Style

Liedert A, Nemitz C, Haffner-Luntzer M, Schick F, Jakob F, Ignatius A. Effects of Estrogen Receptor and Wnt Signaling Activation on Mechanically Induced Bone Formation in a Mouse Model of Postmenopausal Bone Loss. International Journal of Molecular Sciences. 2020; 21(21):8301. https://doi.org/10.3390/ijms21218301

Chicago/Turabian Style

Liedert, Astrid, Claudia Nemitz, Melanie Haffner-Luntzer, Fabian Schick, Franz Jakob, and Anita Ignatius. 2020. "Effects of Estrogen Receptor and Wnt Signaling Activation on Mechanically Induced Bone Formation in a Mouse Model of Postmenopausal Bone Loss" International Journal of Molecular Sciences 21, no. 21: 8301. https://doi.org/10.3390/ijms21218301

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