Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis
Abstract
:1. Introduction
1.1. Epidemiology and Risk Factor of Oral Submucous Fibrosis (OSMF)
1.2. BQ and OSMF—Etiology, Clinical and Histologic Features
2. Genetic Susceptibility and Expression in Tissue/Organ Fibrosis
3. BQ and Collagen Turnover
3.1. Collagen-Related Genes
3.2. Role of Collagen 1A1 and Collagen 1A2 (COL1A1 and COL1A2)
4. BQ and MMPs
4.1. Collagenase-1 (COLase, MMP-1)
4.2. MMP-2 and MMP-9 (Gelatinase-A and Gelatinase-B)
4.3. MMP-3 (Stromelysin-1)
5. BQ and TGF-β
6. BQ and Lysyl Oxidase (LOX)
7. BQ and Cystatin C (CST3)
8. BQ and Plasminogen Activator Inhibitor-1 (PAI-1)
9. BQ and TIMPs
10. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Cheng, R.-H.; Wang, Y.-P.; Chang, J.Y.-F.; Pan, Y.-H.; Chang, M.-C.; Jeng, J.-H. Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis. Int. J. Mol. Sci. 2020, 21, 8104. https://doi.org/10.3390/ijms21218104
Cheng R-H, Wang Y-P, Chang JY-F, Pan Y-H, Chang M-C, Jeng J-H. Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis. International Journal of Molecular Sciences. 2020; 21(21):8104. https://doi.org/10.3390/ijms21218104
Chicago/Turabian StyleCheng, Ru-Hsiu, Yi-Ping Wang, Julia Yu-Fong Chang, Yu-Hwa Pan, Mei-Chi Chang, and Jiiang-Huei Jeng. 2020. "Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis" International Journal of Molecular Sciences 21, no. 21: 8104. https://doi.org/10.3390/ijms21218104