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Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis

by 1,2, 3,4,†, 3,4,†, 1, 1,5,* and 3,4,6,7,*
1
Department of Dentistry, Chang Gung Memorial Hospital, Taipei 105, Taiwan
2
College of Oral Medicine, Taipei Medical University, Taipei 110, Taiwan
3
School of Dentistry, National Taiwan University Medical College, Taipei 100, Taiwan
4
Department of Dentistry, National Taiwan University Hospital, Taipei 100, Taiwan
5
Biomedical Science Team, Department of Nursing, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
6
College of Dental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
7
Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
These authors contributed equally to the 1st author.
Int. J. Mol. Sci. 2020, 21(21), 8104; https://doi.org/10.3390/ijms21218104
Received: 21 August 2020 / Revised: 28 October 2020 / Accepted: 28 October 2020 / Published: 30 October 2020
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Betel quid (BQ) chewing increased the risk of oral cancer and oral submucous fibrosis (OSMF), an oral premalignant disorder (OPMD) with malignant transformation potential. BQ components such as areca nut (AN), trauma by coarse AN fiber, catechin, copper, alkaloids, stimulated reactive oxygen species (ROS), inflammation and cytotoxicity are suggested to be the contributing factors. They may induce tissue inflammation, proliferation of fibroblasts and collagen deposition, myofibroblast differentiation and contraction, collagen cross-links and inhibit collagen phagocytosis, finally leading to the development of OSMF and oral cancer. These events are mediated by BQ components-induced changes of extracellular matrix (ECM) turnover via regulation of TGF-β1, plasminogen activator inhibitor-1 (PAI-1), cystatin, lysyl oxidase (LOX) and tissue inhibitors of metalloproteinases (TIMPs) and metalloproteinases (MMPs). Genetic susceptibility is also involved in these disease processes. Further understanding the molecular mechanisms of BQ-induced OSMF and oral cancer can be helpful for future disease prevention and treatment. View Full-Text
Keywords: areca nut; betel quid; extracellular matrix turnover; genetic susceptibility; oral cancer; submucous fibrosis areca nut; betel quid; extracellular matrix turnover; genetic susceptibility; oral cancer; submucous fibrosis
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MDPI and ACS Style

Cheng, R.-H.; Wang, Y.-P.; Chang, J.Y.-F.; Pan, Y.-H.; Chang, M.-C.; Jeng, J.-H. Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis. Int. J. Mol. Sci. 2020, 21, 8104. https://doi.org/10.3390/ijms21218104

AMA Style

Cheng R-H, Wang Y-P, Chang JY-F, Pan Y-H, Chang M-C, Jeng J-H. Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis. International Journal of Molecular Sciences. 2020; 21(21):8104. https://doi.org/10.3390/ijms21218104

Chicago/Turabian Style

Cheng, Ru-Hsiu, Yi-Ping Wang, Julia Yu-Fong Chang, Yu-Hwa Pan, Mei-Chi Chang, and Jiiang-Huei Jeng. 2020. "Genetic Susceptibility and Protein Expression of Extracellular Matrix Turnover-Related Genes in Oral Submucous Fibrosis" International Journal of Molecular Sciences 21, no. 21: 8104. https://doi.org/10.3390/ijms21218104

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